Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2266299..2266925 Replicon chromosome
Accession NC_009565
Organism Mycobacterium tuberculosis F11

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag TBFG_RS10595 Protein ID WP_003410075.1
Coordinates 2266527..2266925 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag TBFG_RS10590 Protein ID WP_003911750.1
Coordinates 2266299..2266526 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBFG_RS10580 2264338..2264682 - 345 WP_003410065.1 ferredoxin family protein -
TBFG_RS10585 2264871..2266040 - 1170 WP_003899126.1 ATP-binding protein -
TBFG_RS10590 2266299..2266526 + 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
TBFG_RS10595 2266527..2266925 + 399 WP_003410075.1 PIN domain nuclease Toxin
TBFG_RS10600 2267108..2267539 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
TBFG_RS10605 2267640..2268074 + 435 WP_003914358.1 DUF1398 domain-containing protein -
TBFG_RS21385 2268511..2268690 - 180 Protein_2079 hypothetical protein -
TBFG_RS10610 2268751..2269398 + 648 WP_071854215.1 transposase -
TBFG_RS10615 2269352..2269942 + 591 WP_003899131.1 IS110 family transposase -
TBFG_RS10620 2270070..2270444 - 375 Protein_2082 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T22230 WP_003410075.1 NC_009565:2266527-2266925 [Mycobacterium tuberculosis F11]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

>T22230 NC_009565:2266527-2266925 [Mycobacterium tuberculosis F11]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT22230 WP_003911750.1 NC_009565:2266299-2266526 [Mycobacterium tuberculosis F11]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp

>AT22230 NC_009565:2266299-2266526 [Mycobacterium tuberculosis F11]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References