Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1788977..1789614 Replicon chromosome
Accession NZ_CP085949
Organism Haemophilus influenzae strain FDAARGOS_1562

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A121YHB9
Locus tag LK420_RS08705 Protein ID WP_021035685.1
Coordinates 1789210..1789614 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag LK420_RS08700 Protein ID WP_005656316.1
Coordinates 1788977..1789213 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK420_RS08675 (LK420_08675) 1784204..1784944 - 741 WP_005662961.1 YebC/PmpR family DNA-binding transcriptional regulator -
LK420_RS08680 (LK420_08680) 1785104..1785580 - 477 WP_021035689.1 dihydroneopterin triphosphate diphosphatase -
LK420_RS08685 (LK420_08685) 1785602..1787368 - 1767 WP_021035688.1 aspartate--tRNA ligase -
LK420_RS08690 (LK420_08690) 1787587..1788105 + 519 WP_005688985.1 isoprenylcysteine carboxyl methyltransferase family protein -
LK420_RS08695 (LK420_08695) 1788159..1788884 + 726 WP_228003450.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
LK420_RS08700 (LK420_08700) 1788977..1789213 + 237 WP_005656316.1 antitoxin Antitoxin
LK420_RS08705 (LK420_08705) 1789210..1789614 + 405 WP_021035685.1 type II toxin-antitoxin system VapC family toxin Toxin
LK420_RS08710 (LK420_08710) 1789681..1790088 + 408 WP_005688980.1 lactoylglutathione lyase -
LK420_RS08715 (LK420_08715) 1790162..1790851 + 690 WP_021035684.1 ribonuclease T -
LK420_RS08720 (LK420_08720) 1791165..1792517 + 1353 WP_021035683.1 Na+/H+ antiporter family protein -
LK420_RS08725 (LK420_08725) 1792550..1793134 + 585 WP_021035682.1 primosomal replication protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15690.26 Da        Isoelectric Point: 8.9777

>T222299 WP_021035685.1 NZ_CP085949:1789210-1789614 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFSSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

>T222299 NZ_CP117752:c108637-108332 [Enterobacter hormaechei]
ATGCAGTTCACCGTCTACGAATACACACGCGAGAGCCATTATCGTCTTTTTGTGGATGTGCAGAGCGACATTGTCGAGAC
GCCTGGGCGACGCATAGTGATCCCGTTGCTGGAATCGCACCACTTATCAGAAAAGGTTAATCAGCAGCTTTTCCCGGTGG
TTAGCGTCAATGGGAAAGAATACCGTGCCGTGACTTCCGAATTATCCGGAGTCTCTGTCAGTGTCATCGGCGACGCTGTG
GCCGATCTCAGCCATGAGGCAAATGCCATTAAAAATGCCCTGAACCTGATGTTCTGGGGCATTTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT222299 WP_005656316.1 NZ_CP085949:1788977-1789213 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp

>AT222299 NZ_CP117752:c108855-108637 [Enterobacter hormaechei]
ATGAAACACAGAGCCAGCGTCACAGTAGACAAGGAACATTATCTGGAATTACTCGCGGCAGGCGTGAATATTTCGGGACT
GGTGAATGAGGCTATCGGACGGGAAGCCCGGCGCATCCAGGCTGAACGCTGGAAAGCAGAGAACCGGGAAGGGATGGAAG
AGGTAGCGAATTTCATCGCGCAGCACGGCTCTTTTGCCGACGAAAACCGGAGCTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A121YHB9

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References