222296

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 1297343..1297821 Replicon chromosome
Accession NZ_CP085949
Organism Haemophilus influenzae strain FDAARGOS_1562

Toxin (Protein)


Gene name VapD Uniprot ID A0A112WLN3
Locus tag LK420_RS06235 Protein ID WP_021034684.1
Coordinates 1297343..1297621 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0K9KX05
Locus tag LK420_RS06240 Protein ID WP_012055040.1
Coordinates 1297630..1297821 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK420_RS06215 (LK420_06215) 1292531..1294201 - 1671 WP_021034688.1 fructose-specific PTS transporter subunit EIIC -
LK420_RS06220 (LK420_06220) 1294203..1295144 - 942 WP_021034687.1 1-phosphofructokinase -
LK420_RS06225 (LK420_06225) 1295146..1296645 - 1500 WP_021034686.1 fused PTS fructose transporter subunit IIA/HPr protein -
LK420_RS06230 (LK420_06230) 1296717..1297247 - 531 WP_021034685.1 hypothetical protein -
LK420_RS06235 (LK420_06235) 1297343..1297621 - 279 WP_021034684.1 virulence-associated protein VapD Toxin
LK420_RS06240 (LK420_06240) 1297630..1297821 - 192 WP_012055040.1 DUF5397 family protein Antitoxin
LK420_RS06245 (LK420_06245) 1297892..1299190 - 1299 WP_021034683.1 hemolysin family protein -
LK420_RS06250 (LK420_06250) 1299241..1299765 - 525 WP_005669286.1 DUF1523 family protein -
LK420_RS06255 (LK420_06255) 1299792..1300574 - 783 WP_021034682.1 YchF/TatD family DNA exonuclease -
LK420_RS06260 (LK420_06260) 1300610..1301590 - 981 WP_021034681.1 DNA polymerase III subunit delta' -
LK420_RS06265 (LK420_06265) 1301587..1302219 - 633 WP_041175393.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10647.01 Da        Isoelectric Point: 4.9670

>T222296 WP_021034684.1 NZ_CP085949:c1297621-1297343 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAVLAKFGFVRTQGSLYTNTNEDMANLFQAMNELKQLAWISQSVRDIRAFRI
EQWSDFTDFIRS

Download         Length: 279 bp

>T222296 NZ_CP117750:c4410549-4410247 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
CTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCTGTGGGCGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGGATCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7018.97 Da        Isoelectric Point: 3.9930

>AT222296 WP_012055040.1 NZ_CP085949:c1297821-1297630 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDALVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT222296 NZ_CP117750:c4410240-4409953 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGCTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A112WLN3

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9KX05

References