Detailed information of TA system TA222293

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 929678..930362
• Replicon: chromosome
• Accession: NZ_CP085947
• Organism: Helicobacter pylori strain FDAARGOS_1563

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LK447_RS04475
• Protein ID: WP_000912777.1
• Coordinates: 929678..930004 (-)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B5Z7Q4
• Locus tag: LK447_RS04480
• Protein ID: WP_001134069.1
• Coordinates: 929991..930362 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LK447_RS04450 (LK447_04450)	924954..925643	-	690	WP_000270095.1	hypothetical protein	-
LK447_RS04455 (LK447_04455)	925643..926760	-	1118	Protein_865	site-specific DNA-methyltransferase	-
LK447_RS04460 (LK447_04460)	926854..927222	+	369	WP_000337921.1	hypothetical protein	-
LK447_RS04465 (LK447_04465)	927222..928184	+	963	WP_001124288.1	GTP-binding protein	-
LK447_RS04470 (LK447_04470)	928190..929335	-	1146	WP_001263623.1	YbfB/YjiJ family MFS transporter	-
LK447_RS04475 (LK447_04475)	929678..930004	-	327	WP_000912777.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
LK447_RS04480 (LK447_04480)	929991..930362	-	372	WP_001134069.1	hypothetical protein	Antitoxin
LK447_RS04485 (LK447_04485)	930765..932999	-	2235	WP_000716273.1	Hop family adhesin BabA	-
LK447_RS04490 (LK447_04490)	933268..934023	-	756	WP_000934615.1	HugZ family heme oxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12686.20 Da
• Isoelectric Point: 10.4541

>T222293 WP_000912777.1 NZ_CP085947:c930004-929678 [Helicobacter pylori]
MLKIKHHILYKKDFKKLVKNGFDDSVLNKVILTLRKKEPLDPQFQDHALKGKWKPFRECHIKPDILLVYLVKDDELILLR
LGSHSELFYKPPITLKKNTTIAVNSKPL

Nucleotide

• Length: 327 bp

>T222293 NZ_CP117750:4169811-4170065 [Enterobacter hormaechei]
GTGAAGATCACATGGTCTGAAGAGGCATGGGAAGACTACCTCTATTGGCAGGAGACCGATAAGCGCATGGTGAAGAAAAT
CAATGAGCTTATCAAAATCTCCTGTCGCACTCCGTTTGAGGGGATCGGCAAGCCAGAGCCATTAAAACATAACCTGGCTG
GCTTCTGGTCTCGCCGAATCACCTCTGAGCATCGCATGGTCTATGCCATCACAGAAGAAGCGATCCTCATAGCTGCGTGC
CGATATCACTACTGA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 14602.53 Da
• Isoelectric Point: 7.2781

>AT222293 WP_001134069.1 NZ_CP085947:c930362-929991 [Helicobacter pylori]
MPNTTAKKDYTKYSEKQLFNLIHQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCYL
GHKIPNLETQQAMRDALNGENLETIEDFHAWANEVKKEVNAEN

Nucleotide

• Length: 372 bp

>AT222293 NZ_CP117750:4169563-4169814 [Enterobacter hormaechei]
ATGCGTGTTATTAGTTACAGTGAAGCCCGACAAAACCTGTCGGCAACAATGGTCCAGACGACGGAAGATCGCGCGCCGGT
GCTTATTACGCGCCAGAACGGTGAATCTTGTGTTCTGATGTCGCTGGAAGAGTACAACTCGCTTGAAGAAACCGCATACC
TGATGCGCTCCCCGGCAAACGCAAAACGTCTGATGAACTCTATCGAGAGCTTGAAATCTGGTGGCGGGAAGGAAAGGGAC
ATTATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: B5Z7Q4