Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 5081415..5082082 Replicon chromosome
Accession NZ_CP085945
Organism Mycobacterium intracellulare strain FDAARGOS_1564

Toxin (Protein)


Gene name vapC Uniprot ID D5PE24
Locus tag LK403_RS23640 Protein ID WP_007168407.1
Coordinates 5081690..5082082 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5PE23
Locus tag LK403_RS23635 Protein ID WP_007168406.1
Coordinates 5081415..5081690 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK403_RS23605 (LK403_23605) 5077235..5077468 - 234 Protein_4682 transposase -
LK403_RS23610 (LK403_23610) 5077489..5078649 - 1161 Protein_4683 ISL3 family transposase -
LK403_RS23615 (LK403_23615) 5078821..5079465 - 645 WP_019731991.1 DDE-type integrase/transposase/recombinase -
LK403_RS23625 (LK403_23625) 5079604..5080307 - 704 Protein_4685 phosphoglycerate mutase family protein -
LK403_RS23630 (LK403_23630) 5080390..5081262 + 873 WP_007168405.1 MaoC/PaaZ C-terminal domain-containing protein -
LK403_RS23635 (LK403_23635) 5081415..5081690 + 276 WP_007168406.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LK403_RS23640 (LK403_23640) 5081690..5082082 + 393 WP_007168407.1 type II toxin-antitoxin system VapC family toxin Toxin
LK403_RS23645 (LK403_23645) 5082230..5083389 - 1160 Protein_4689 trehalose-phosphatase -
LK403_RS23650 (LK403_23650) 5083431..5084769 - 1339 Protein_4690 WS/DGAT domain-containing protein -
LK403_RS23655 (LK403_23655) 5084928..5085152 - 225 Protein_4691 IS1595 family transposase -
LK403_RS23660 (LK403_23660) 5085414..5086823 + 1410 Protein_4692 IS1182 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-45)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14305.73 Da        Isoelectric Point: 10.5032

>T222291 WP_007168407.1 NZ_CP085945:5081690-5082082 [Mycobacterium intracellulare]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRLPRVSSALARTEVMRALLHKGESARRAGRRALASLDLLRIDNRLLDLAG
GLLPIELRTLDAIHLATAQRLGMDLGRLCTYDDRMRDAAEALGMAVIAPS

Download         Length: 393 bp

>T222291 NZ_CP117750:4117034-4117348 [Enterobacter hormaechei]
ATGCATTTAATCTCAATGAAGGCAATTTTGGATGCGGTAAGCCAGTTCCCGCAACACAGAGAAGAGCTTCTCTTTTTAGG
ACGAGTTATTGAAAAGAGCCACTGCCCGACGCCCGCTGCACTGAGAAAACTTTTCCCAACGCTGGATAACTTCAAGTATC
TTGATAAGCATTATGTTATTGATATTGCAAATAACAATCTCAGAGTAGTGGCTCTCATATTCTTTGAAAGCCAAAAGTTT
TATGTGCGCCATGTTTTTACTCATAAGGAATATGACCGTTTTACGGAGAAACATCGCACTAAGGGGAAGAAATGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10150.63 Da        Isoelectric Point: 5.1881

>AT222291 WP_007168406.1 NZ_CP085945:5081415-5081690 [Mycobacterium intracellulare]
MSTVGVRELRQRASELLRRVEAGETIEITDRGRPIALLSPMPEGGPYQQMLASGGIERATLDFDDLPEPVRLKTGIELPS
VTLARLREHER

Download         Length: 276 bp

>AT222291 NZ_CP117750:4117348-4117764 [Enterobacter hormaechei]
ATGATCGTCGCTGATGCAATGAAAGCTACGCACGCCCTTGTTGCGGCCGTTCCTTTACTGGGTGAACAGCCGAGCGAGAA
AGATTATAAGGATGCGCTTGAGCTGGTTGAGTATCTCCTTATGAACGAGCCCAATAGTCCTTTGCTGGATATTGTGTGCG
CCAGAATTAGCCATTACGAAGCTAATGGGCCAGAGATAGTCGCATTACGCAAGGAGATGGAGTCCGTTCCCGTCGGAATT
GCAGTTTTAAGAACCTTGATGGATCAATACAATCTGACGATATCGGATTTTAAGGATGAAATTGGTAGTAAATCGATGGT
TTCACGGGTTCTGAATGGTCAGAGACAGCTTACCCTGAACCATATTAAAAAGCTGGCGGCCAGATTTGGGGTATCACCTG
CGTTATTTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XV84

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XUZ3

References