Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3137729..3138282 Replicon chromosome
Accession NZ_CP085945
Organism Mycobacterium intracellulare strain FDAARGOS_1564

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LK403_RS14750 Protein ID WP_036458935.1
Coordinates 3137729..3138001 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LK403_RS14755 Protein ID WP_080687338.1
Coordinates 3138001..3138282 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK403_RS14730 (LK403_14730) 3133199..3133729 - 531 WP_051444546.1 hypothetical protein -
LK403_RS14735 (LK403_14735) 3133989..3135302 + 1314 WP_227958410.1 thiolase family protein -
LK403_RS14740 (LK403_14740) 3135396..3136379 - 984 WP_051444545.1 helix-turn-helix domain-containing protein -
LK403_RS14745 (LK403_14745) 3136811..3137482 + 672 WP_036458937.1 hypothetical protein -
LK403_RS14750 (LK403_14750) 3137729..3138001 - 273 WP_036458935.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LK403_RS14755 (LK403_14755) 3138001..3138282 - 282 WP_080687338.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LK403_RS14760 (LK403_14760) 3139092..3139322 - 231 WP_095577121.1 DUF6400 family protein -
LK403_RS14765 (LK403_14765) 3139564..3140391 - 828 WP_036458929.1 thioesterase family protein -
LK403_RS14770 (LK403_14770) 3140418..3141425 - 1008 WP_036458927.1 GTP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3077968..3143522 65554


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-73)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10514.17 Da        Isoelectric Point: 11.8438

>T222286 WP_036458935.1 NZ_CP085945:c3138001-3137729 [Mycobacterium intracellulare]
MQPADYTVRFTATARRDLHKLPPRVLSAVIEFAFGDLAHEPRRVGKPLRRELAGLYSARRGPYRLLYRIDGGRSRVLIQR
VDHRADVYRR

Download         Length: 273 bp

>T222286 NZ_CP117750:c1608622-1608137 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGTGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGGAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATACCCGTGATTATACTTGCCCGTCTGGCTGTGGATGTCTCGCTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTCAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCC
CAGTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10305.56 Da        Isoelectric Point: 4.3224

>AT222286 WP_080687338.1 NZ_CP085945:c3138282-3138001 [Mycobacterium intracellulare]
VRILPISKMKDKLNEYVDAVAKTQDQITITKNGAPAAVLVGAEEWESLQETLYWLSRPGIKDSIAEADADIAAGRTYDED
EIRAEFGVPRRAD

Download         Length: 282 bp

>AT222286 NZ_CP117750:c1608876-1608610 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCGCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References