Detailed information of TA system TA222283

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 548026..548676
• Replicon: chromosome
• Accession: NZ_CP085923
• Organism: Helicobacter pylori strain FDAARGOS_1601

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LK454_RS02680
• Protein ID: WP_189394512.1
• Coordinates: 548416..548676 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I0ZDA3
• Locus tag: LK454_RS02675
• Protein ID: WP_001134036.1
• Coordinates: 548026..548337 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LK454_RS02650 (LK454_02650)	544403..545170	-	768	WP_000242348.1	ABC transporter ATP-binding protein	-
LK454_RS02655 (LK454_02655)	545170..546150	-	981	WP_000921461.1	iron ABC transporter permease	-
LK454_RS02660 (LK454_02660)	546143..546997	-	855	WP_000538066.1	SDR family oxidoreductase	-
LK454_RS02665 (LK454_02665)	547137..547661	+	525	WP_001135616.1	acyl-CoA thioesterase	-
LK454_RS02670 (LK454_02670)	547767..548039	-	273	WP_000955517.1	type II toxin-antitoxin system mRNA interferase toxin, HP0892 family	-
LK454_RS02675 (LK454_02675)	548026..548337	-	312	WP_001134036.1	type II toxin-antitoxin system antitoxin	Antitoxin
LK454_RS02680 (LK454_02680)	548416..548676	-	261	WP_189394512.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LK454_RS02685 (LK454_02685)	548657..549034	-	378	WP_001134047.1	hypothetical protein	-
LK454_RS02690 (LK454_02690)	549496..551709	-	2214	WP_227956582.1	Hop family adhesin BabA	-
LK454_RS02705 (LK454_02705)	552133..552761	+	629	Protein_533	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10071.92 Da
• Isoelectric Point: 8.0536

>T222283 WP_189394512.1 NZ_CP085923:c548676-548416 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILRKKEPLPLPFKDHALKGVWKPYRECHIKADILLVYLVQDDELILLRLG
SHSELF

Nucleotide

• Length: 261 bp

>T222283 NZ_CP117750:c336824-336606 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTTGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTGTGGAAATTTGTTCGTTAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12256.05 Da
• Isoelectric Point: 10.0373

>AT222283 WP_001134036.1 NZ_CP085923:c548337-548026 [Helicobacter pylori]
MPNTTAEKDYTKYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALNLTENGYTIEEEREILARAKDTKNH
LCFKSVEDFKKHCENLRFKNADD

Nucleotide

• Length: 312 bp

>AT222283 NZ_CP117750:c337226-336852 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTCAACGAGTTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Structures

Antitoxin

• AlphaFold DB: I0ZDA3