Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 191207..191736 Replicon chromosome
Accession NZ_CP085906
Organism Enterococcus faecium strain SC1762-D

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag LLE91_RS00940 Protein ID WP_002294198.1
Coordinates 191470..191736 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag LLE91_RS00935 Protein ID WP_002294199.1
Coordinates 191207..191470 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE91_RS00925 (LLE91_00925) 188582..190405 + 1824 WP_002294202.1 APC family permease -
LLE91_RS00930 (LLE91_00930) 190547..190732 - 186 WP_002294201.1 hypothetical protein -
LLE91_RS00935 (LLE91_00935) 191207..191470 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LLE91_RS00940 (LLE91_00940) 191470..191736 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
LLE91_RS00945 (LLE91_00945) 191937..192425 + 489 WP_002294196.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
LLE91_RS00950 (LLE91_00950) 192488..192655 + 168 WP_002294195.1 hypothetical protein -
LLE91_RS00955 (LLE91_00955) 192967..193620 - 654 WP_002317081.1 ABC transporter permease -
LLE91_RS00960 (LLE91_00960) 193635..194552 - 918 WP_002294193.1 osmoprotectant ABC transporter substrate-binding protein -
LLE91_RS00965 (LLE91_00965) 194549..195190 - 642 WP_002293405.1 ABC transporter permease -
LLE91_RS00970 (LLE91_00970) 195194..196369 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 196515..197474 959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T222274 WP_002294198.1 NZ_CP085906:191470-191736 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T222274 NZ_CP117749:c151267-150986 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT222274 WP_002294199.1 NZ_CP085906:191207-191470 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT222274 NZ_CP117749:c151491-151264 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCTGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References