Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2233667..2234355 Replicon chromosome
Accession NC_009565
Organism Mycobacterium tuberculosis F11

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag TBFG_RS10425 Protein ID WP_003409958.1
Coordinates 2233667..2234086 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag TBFG_RS10430 Protein ID WP_003409968.1
Coordinates 2234095..2234355 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBFG_RS10405 2229162..2230010 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
TBFG_RS10410 2229973..2231418 - 1446 WP_003899115.1 APC family permease -
TBFG_RS10415 2231597..2232283 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
TBFG_RS10420 2232474..2233442 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
TBFG_RS10425 2233667..2234086 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
TBFG_RS10430 2234095..2234355 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
TBFG_RS10435 2234498..2236174 + 1677 WP_012054305.1 PecA family PE domain-processing aspartic protease -
TBFG_RS10440 2236162..2236815 - 654 WP_003409976.1 cutinase Cfp21 -
TBFG_RS10445 2236930..2237160 + 231 WP_003409980.1 DUF167 domain-containing protein -
TBFG_RS10450 2237245..2238156 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
TBFG_RS10455 2238265..2238864 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T22227 WP_003409958.1 NC_009565:c2234086-2233667 [Mycobacterium tuberculosis F11]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T22227 NC_009565:c2234086-2233667 [Mycobacterium tuberculosis F11]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT22227 WP_003409968.1 NC_009565:c2234355-2234095 [Mycobacterium tuberculosis F11]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT22227 NC_009565:c2234355-2234095 [Mycobacterium tuberculosis F11]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References