Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 191328..191857 Replicon chromosome
Accession NZ_CP085894
Organism Enterococcus faecium strain SC1762

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag LK894_RS00940 Protein ID WP_002294198.1
Coordinates 191591..191857 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag LK894_RS00935 Protein ID WP_002294199.1
Coordinates 191328..191591 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK894_RS00925 (LK894_00925) 188703..190526 + 1824 WP_002294202.1 APC family permease -
LK894_RS00930 (LK894_00930) 190668..190853 - 186 WP_002294201.1 hypothetical protein -
LK894_RS00935 (LK894_00935) 191328..191591 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LK894_RS00940 (LK894_00940) 191591..191857 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
LK894_RS00945 (LK894_00945) 192058..192546 + 489 WP_002294196.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
LK894_RS00950 (LK894_00950) 192609..192776 + 168 WP_002294195.1 hypothetical protein -
LK894_RS00955 (LK894_00955) 193088..193741 - 654 WP_002317081.1 ABC transporter permease -
LK894_RS00960 (LK894_00960) 193756..194673 - 918 WP_002294193.1 osmoprotectant ABC transporter substrate-binding protein -
LK894_RS00965 (LK894_00965) 194670..195311 - 642 WP_002293405.1 ABC transporter permease -
LK894_RS00970 (LK894_00970) 195315..196490 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 196636..197595 959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T222266 WP_002294198.1 NZ_CP085894:191591-191857 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T222266 NZ_CP117745:4108933-4109151 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT222266 WP_002294199.1 NZ_CP085894:191328-191591 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT222266 NZ_CP117745:4108532-4108906 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References