222264

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 3355..3935 Replicon plasmid p4
Accession NZ_CP085893
Organism Klebsiella pneumoniae strain 8695

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag LKW25_RS29385 Protein ID WP_071177730.1
Coordinates 3355..3669 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag LKW25_RS29390 Protein ID WP_000093040.1
Coordinates 3657..3935 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKW25_RS29355 (LKW25_29355) 1..1257 + 1257 WP_228015059.1 TraM recognition domain-containing protein -
LKW25_RS29360 (LKW25_29360) 1257..1547 + 291 WP_228015061.1 replication-relaxation family protein -
LKW25_RS29365 (LKW25_29365) 1675..1992 + 318 WP_228015063.1 hypothetical protein -
LKW25_RS29370 (LKW25_29370) 1999..2229 + 231 WP_228015065.1 hypothetical protein -
LKW25_RS29375 (LKW25_29375) 2558..2737 - 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
LKW25_RS29380 (LKW25_29380) 2763..3191 - 429 WP_001140599.1 hypothetical protein -
LKW25_RS29385 (LKW25_29385) 3355..3669 - 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LKW25_RS29390 (LKW25_29390) 3657..3935 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
LKW25_RS29395 (LKW25_29395) 4110..4475 - 366 WP_072354022.1 TonB family protein -
LKW25_RS29400 (LKW25_29400) 4472..4843 - 372 WP_001237044.1 cell envelope integrity protein TolA -
LKW25_RS29405 (LKW25_29405) 5117..5362 - 246 WP_032440458.1 hypothetical protein -
LKW25_RS29410 (LKW25_29410) 6007..7496 + 1490 Protein_11 group II intron reverse transcriptase/maturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..23957 23957


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T222264 WP_071177730.1 NZ_CP085893:c3669-3355 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

>T222264 NZ_CP117745:2024196-2024298 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT222264 WP_000093040.1 NZ_CP085893:c3935-3657 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp

>AT222264 NZ_CP117745:c2024305-2024160 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References