Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 36468..37104 Replicon plasmid pHN2
Accession NZ_CP085886
Organism Pseudomonas sp. HN2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LIS66_RS27335 Protein ID WP_227974596.1
Coordinates 36468..36650 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LIS66_RS27340 Protein ID WP_227974597.1
Coordinates 36682..37104 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIS66_RS27310 (LIS66_27310) 31658..32671 + 1014 WP_227974591.1 hypothetical protein -
LIS66_RS27315 (LIS66_27315) 33445..33831 + 387 WP_227974592.1 hypothetical protein -
LIS66_RS27320 (LIS66_27320) 34044..34370 + 327 WP_227974593.1 hypothetical protein -
LIS66_RS27325 (LIS66_27325) 34418..35887 + 1470 WP_227974594.1 hypothetical protein -
LIS66_RS27330 (LIS66_27330) 36031..36366 + 336 WP_227974595.1 hypothetical protein -
LIS66_RS27335 (LIS66_27335) 36468..36650 + 183 WP_227974596.1 type II toxin-antitoxin system HicA family toxin Toxin
LIS66_RS27340 (LIS66_27340) 36682..37104 + 423 WP_227974597.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LIS66_RS27345 (LIS66_27345) 37104..37511 + 408 WP_227974598.1 S24 family peptidase -
LIS66_RS27350 (LIS66_27350) 37495..38031 + 537 WP_227974599.1 hypothetical protein -
LIS66_RS27355 (LIS66_27355) 38051..38362 + 312 WP_227974600.1 hypothetical protein -
LIS66_RS27360 (LIS66_27360) 38377..38811 + 435 WP_227974601.1 hypothetical protein -
LIS66_RS27365 (LIS66_27365) 38897..39094 + 198 WP_227974602.1 hypothetical protein -
LIS66_RS27370 (LIS66_27370) 39274..39546 + 273 WP_227974603.1 hypothetical protein -
LIS66_RS27375 (LIS66_27375) 39582..40214 + 633 WP_227974604.1 hypothetical protein -
LIS66_RS27380 (LIS66_27380) 40298..40693 + 396 WP_227974606.1 hypothetical protein -
LIS66_RS27385 (LIS66_27385) 40690..40938 + 249 WP_227974607.1 hypothetical protein -
LIS66_RS27390 (LIS66_27390) 40935..41249 + 315 WP_227974608.1 hypothetical protein -
LIS66_RS27395 (LIS66_27395) 41246..41671 + 426 WP_227974554.1 hypothetical protein -
LIS66_RS27400 (LIS66_27400) 41755..42015 + 261 WP_227974555.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..81985 81985


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6868.01 Da        Isoelectric Point: 10.5498

>T222235 WP_227974596.1 NZ_CP085886:36468-36650 [Pseudomonas sp. HN2]
MKCSEFRRWLVAQGVEFKSAKGSHFKVYLNGKSTIFADHGSKEMHEGLRKTIIKQLGLKD

Download         Length: 183 bp

>T222235 NZ_CP117730:1047646-1047903 [Klebsiella grimontii]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACGTTCGCGATGCATC
AGGCCGCGTCACTTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCCTATCGCATCAATACCACCGGGCTGAATAATGTCCGCGCA
CAGCTGGATAATCGCTAA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15369.81 Da        Isoelectric Point: 4.9408

>AT222235 WP_227974597.1 NZ_CP085886:36682-37104 [Pseudomonas sp. HN2]
MYQYPLELHTEPTGVWLSCPDVPEMNASGDTLGEAFAEALNGLESALSLYVEQRRKIPAASPAQDPALVLRLPALTVAKI
MLWNAMCDEGVSRAELARRLGVSRQMVDRLVDFLHASKIEQVERALGLLGRRLSLVLEAA

Download         Length: 423 bp

>AT222235 NZ_CP117730:1047914-1048465 [Klebsiella grimontii]
ATGACAAACCACAGCTTCACTTTTCATGTCGCCTCTGAAGGCGATACCAATGACATTCTCCATGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCGATTTGCTCAACGATGAGAGCGCCTGCCCGACGTTATCGCTGCTGGCCA
GGCATAACGGAAAGGCGGTTGGGCATATTTTATTCACCCGGGCGACGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTTGCGGTGGTGCCGGAATACCAGGGCGCGGGCGTTGGCGGAGGGCTTATCCGGCACGGCATTGAGCA
GTTGAAAGCCATGGGAAGCCAGACGGTATTTGTTCTGGGCCACGCCACTTACTACCCCAGGCATGGGTTTGAGCCATGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCCATTCCCGAGGCGCTCAAAGCCTGCTGGATGCTGCAGCCGCTTTCATCT
CAGCCGCTGGGACGAACGGGTCAAATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References