Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 5997812..5999436 Replicon chromosome
Accession NZ_CP085885
Organism Pseudomonas sp. HN2

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LIS66_RS26760 Protein ID WP_227973331.1
Coordinates 5998087..5999436 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID V8R249
Locus tag LIS66_RS26755 Protein ID WP_024014849.1
Coordinates 5997812..5998090 (-) Length 93 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIS66_RS26725 (LIS66_26725) 5993243..5993866 + 624 WP_227973328.1 FMN-binding negative transcriptional regulator -
LIS66_RS26730 (LIS66_26730) 5993877..5994323 + 447 WP_116657238.1 GNAT family N-acetyltransferase -
LIS66_RS26735 (LIS66_26735) 5994336..5995007 + 672 WP_227973329.1 GNAT family protein -
LIS66_RS26740 (LIS66_26740) 5995129..5996031 - 903 WP_227973330.1 homocysteine S-methyltransferase family protein -
LIS66_RS26745 (LIS66_26745) 5996145..5996963 + 819 WP_042608054.1 ABC transporter substrate-binding protein -
LIS66_RS26750 (LIS66_26750) 5996960..5997796 + 837 WP_064365163.1 amino acid ABC transporter permease -
LIS66_RS26755 (LIS66_26755) 5997812..5998090 - 279 WP_024014849.1 helix-turn-helix transcriptional regulator Antitoxin
LIS66_RS26760 (LIS66_26760) 5998087..5999436 - 1350 WP_227973331.1 HipA domain-containing protein Toxin
LIS66_RS26765 (LIS66_26765) 5999547..5999747 - 201 WP_227973332.1 hypothetical protein -
LIS66_RS26770 (LIS66_26770) 5999804..6001999 + 2196 WP_227973333.1 autotransporter outer membrane beta-barrel domain-containing protein -
LIS66_RS26775 (LIS66_26775) 6002194..6004002 - 1809 WP_116657233.1 sodium-extruding oxaloacetate decarboxylase subunit alpha -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(165-367)

Antitoxin

(27-80)


Sequences


Toxin        


Download         Length: 450 a.a.        Molecular weight: 49905.45 Da        Isoelectric Point: 5.0771

>T222234 WP_227973331.1 NZ_CP085885:c5999436-5998087 [Pseudomonas sp. HN2]
MYNLTLQIFTAGQWHDAMTLDFDDPEKGFESRCSFGYEADYLVENIELIGSPFSQAVSALYPLDWEGRRAKTPAFVHDIA
PAGAAKRFLLARLGQERPAEISADLFLLGRRTPAPIGNMRIKESAEAVDERKPIGFKREEVISRDNRFLEYAYELGAAIG
GATGAGGEAPKLLLAENSAGLLYPDAVLDDEEVRQHWFVKFARNRGGQTDQDILRSEFHYYKALQTLGIETVAAEGLALE
EANKPSLWMRRFDRQVEDGAVSRFAVESIYSLAEVTTPGSAMNHLDVIRMLAGLWRKAGQASQIPGLVADYLRRDLINKI
LGNSDNHGRNTAIIRQENAFRLAPIYDLAPMVMDDEGVTRTTKWPKELERAGDVDWRGVCRVLADSADPHDSLAGLDASA
LFEGLRADARRLAALPDILAASGLPARTMNHPSVHLKNLEQRLKEWDLQ

Download         Length: 1350 bp

>T222234 NZ_CP117730:c350218-349841 [Klebsiella grimontii]
ATGAAAATATTATCAGACTCCCCCACACGGGCGGCGCCGTCGCGCCCGTCTCCCGTTGAAATCTGGCAGACTCTGTTGAC
GTACCTGCTGGATCAGCACTACGGTCTTACGCTTAACGACACACCGTTTGGCCACGATGGCGTGATCCAGGAGCATATTG
GCACCGGGATCACCCTGTGTGATGCGGTGAATCTTATCGTCGAAAAATACAAACTGGTCCGTATCGATCGTCACGGTTTC
AGCGCAGACACACAGTCACCGCTTATCGGCAGTATCGATATCCTGCGGGCCCGAAAAGAAACTGGGCTGATGACCCGCCA
TGGCTACAGAGCGATTACTGATATCACGACGGGTAAATACAGTGAGGCCGGGCAATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10318.09 Da        Isoelectric Point: 10.7364

>AT222234 WP_024014849.1 NZ_CP085885:c5998090-5997812 [Pseudomonas sp. HN2]
MSLTVLERTALIESIQQSLAEGTLEIGDAVRRLRVEVTGLHQTQFAKMCKISVRTLVHIEHGEGNQTLKSLNAVFRPFGM
KMGVVRIRRDTV

Download         Length: 279 bp

>AT222234 NZ_CP117730:c350618-350259 [Klebsiella grimontii]
TTGTCGAAGAAAACCACGATAACAACGCATGATATCAGCGAACCCTGGTGGGGGCTCAGGCGCAGTGTCTCTCCGTGTTT
TGGGGCCCGTCTGGTCCAGGAGGGGAATCGGCTGAATTATCTGGCTGACCGTGCGAACTTTGATGGTCAGTTCTGCGATG
CGGATTTGCGCCATCTTGACCAGGCTTTCCCGGTATTGATGAAACAGCTGGAGTTAATGCTTACCAGCGGTGAACTGAAT
CCCCGTCATCAGCACTGCGTCACGCTGTATGCAAAAGGTCTGACCTGCGAGGCCGATACCCTCGGCTCACACGGTTACCT
TTACCTCGCGATTTACACAACGCCTGCTACTGCCGCATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A1N7C5J7

References