Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 4947455..4947960 Replicon chromosome
Accession NZ_CP085885
Organism Pseudomonas sp. HN2

Toxin (Protein)


Gene name relE Uniprot ID A0A2U1R9I4
Locus tag LIS66_RS21840 Protein ID WP_042608353.1
Coordinates 4947706..4947960 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1N7ATY6
Locus tag LIS66_RS21835 Protein ID WP_042608352.1
Coordinates 4947455..4947709 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIS66_RS21810 (LIS66_21810) 4943136..4943465 + 330 WP_227973031.1 hypothetical protein -
LIS66_RS21815 (LIS66_21815) 4943484..4943852 - 369 WP_039761415.1 PH domain-containing protein -
LIS66_RS21820 (LIS66_21820) 4944017..4944388 + 372 WP_227973032.1 hypothetical protein -
LIS66_RS21825 (LIS66_21825) 4944481..4945233 + 753 WP_042608350.1 hypothetical protein -
LIS66_RS21830 (LIS66_21830) 4945304..4947223 + 1920 WP_227973033.1 alkaline phosphatase D family protein -
LIS66_RS21835 (LIS66_21835) 4947455..4947709 + 255 WP_042608352.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LIS66_RS21840 (LIS66_21840) 4947706..4947960 + 255 WP_042608353.1 Txe/YoeB family addiction module toxin Toxin
LIS66_RS21845 (LIS66_21845) 4947954..4949141 - 1188 WP_042608354.1 aspartate aminotransferase family protein -
LIS66_RS21850 (LIS66_21850) 4949244..4950164 + 921 WP_227973034.1 LysR family transcriptional regulator -
LIS66_RS21855 (LIS66_21855) 4950204..4950608 + 405 WP_227973035.1 GNAT family N-acetyltransferase -
LIS66_RS21860 (LIS66_21860) 4950742..4951443 + 702 WP_064364315.1 hypothetical protein -
LIS66_RS21865 (LIS66_21865) 4951700..4952191 - 492 WP_016773306.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9967.53 Da        Isoelectric Point: 9.0627

>T222232 WP_042608353.1 NZ_CP085885:4947706-4947960 [Pseudomonas sp. HN2]
MKIEFTPTGWEDYLWFQQNDKAGLKRINLLIKAIKREPFEGVGKPEALKHNMSGLWSRRVTAEHRLVYRVEDGEICVISC
RYHY

Download         Length: 255 bp

>T222232 NZ_CP117729:2762-3049 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9503.96 Da        Isoelectric Point: 7.0130

>AT222232 WP_042608352.1 NZ_CP085885:4947455-4947709 [Pseudomonas sp. HN2]
MQTINYTTARAHLAETMDRVNEDRAPLLVTRQKGEPVVMMSLAEYNALEETAYLLRSPANAERLMKSIGELRAGKAKVRQ
LIEE

Download         Length: 255 bp

>AT222232 NZ_CP117729:3036-3350 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U1R9I4

Antitoxin

Source ID Structure
AlphaFold DB A0A1N7ATY6

References