Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4568678..4569296 Replicon chromosome
Accession NZ_CP085885
Organism Pseudomonas sp. HN2

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag LIS66_RS20220 Protein ID WP_227974540.1
Coordinates 4568678..4568989 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag LIS66_RS20225 Protein ID WP_227972913.1
Coordinates 4568979..4569296 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIS66_RS20195 (LIS66_20195) 4564472..4565503 - 1032 WP_227972909.1 hypothetical protein -
LIS66_RS20200 (LIS66_20200) 4565675..4566394 - 720 WP_227972910.1 hypothetical protein -
LIS66_RS20205 (LIS66_20205) 4566472..4567287 - 816 WP_227972911.1 sulfite exporter TauE/SafE family protein -
LIS66_RS20210 (LIS66_20210) 4567401..4568168 + 768 WP_065616764.1 helix-turn-helix transcriptional regulator -
LIS66_RS20215 (LIS66_20215) 4568262..4568579 + 318 WP_227972912.1 XRE family transcriptional regulator -
LIS66_RS20220 (LIS66_20220) 4568678..4568989 + 312 WP_227974540.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIS66_RS20225 (LIS66_20225) 4568979..4569296 + 318 WP_227972913.1 helix-turn-helix transcriptional regulator Antitoxin
LIS66_RS20230 (LIS66_20230) 4569307..4570359 - 1053 WP_227972914.1 MBL fold metallo-hydrolase -
LIS66_RS20235 (LIS66_20235) 4570571..4571179 + 609 WP_227972915.1 TetR/AcrR family transcriptional regulator -
LIS66_RS20240 (LIS66_20240) 4571413..4572732 + 1320 WP_227972916.1 PAS domain-containing methyl-accepting chemotaxis protein -
LIS66_RS20245 (LIS66_20245) 4572897..4573223 - 327 WP_227972917.1 DUF2025 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4553986..4569296 15310


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(1-88)

Antitoxin

Cro/C1-type helix-turn-helix domain

(29-84)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11387.87 Da        Isoelectric Point: 6.8600

>T222231 WP_227974540.1 NZ_CP085885:4568678-4568989 [Pseudomonas sp. HN2]
MPTEVQDVFGHALDLAQCGLKYSDAKPLKGFVGAGVLELIEDFDTDTYRAVYTVRFGSAIYVLHCFQKKSKSGIKTAQTD
IDLIRNRLRAAQEHAKGSENHGD

Download         Length: 312 bp

>T222231 NZ_CP117728:448294-448683 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11565.56 Da        Isoelectric Point: 10.1490

>AT222231 WP_227972913.1 NZ_CP085885:4568979-4569296 [Pseudomonas sp. HN2]
MEIEVGSGNVYQDLDLPNASEMQVKSQLAAKIGAIIKARHLTQIQASEILGLSQPKLSEMLRGKFRGISEAKMMECLARL
GRDVQIVVKSAPRSRKEGRIEVVFA

Download         Length: 318 bp

>AT222231 NZ_CP117728:448030-448287 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References