Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2326330..2326934 Replicon chromosome
Accession NZ_CP085885
Organism Pseudomonas sp. HN2

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LIS66_RS10305 Protein ID WP_042609483.1
Coordinates 2326641..2326934 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag LIS66_RS10300 Protein ID WP_042609482.1
Coordinates 2326330..2326638 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIS66_RS10275 (LIS66_10275) 2321466..2322089 + 624 WP_016774080.1 isochorismate family cysteine hydrolase YcaC -
LIS66_RS10280 (LIS66_10280) 2322301..2323728 - 1428 WP_227974176.1 mechanosensitive ion channel family protein -
LIS66_RS10285 (LIS66_10285) 2323837..2324859 - 1023 WP_227974177.1 alpha/beta hydrolase -
LIS66_RS10290 (LIS66_10290) 2325020..2325919 + 900 WP_024012435.1 LysR family transcriptional regulator -
LIS66_RS10295 (LIS66_10295) 2325991..2326257 - 267 WP_227974502.1 type II toxin-antitoxin system RelE/ParE family toxin -
LIS66_RS10300 (LIS66_10300) 2326330..2326638 - 309 WP_042609482.1 putative addiction module antidote protein Antitoxin
LIS66_RS10305 (LIS66_10305) 2326641..2326934 - 294 WP_042609483.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIS66_RS10310 (LIS66_10310) 2327162..2327854 - 693 WP_227974178.1 N-acetyltransferase -
LIS66_RS10315 (LIS66_10315) 2327851..2329041 - 1191 WP_227974179.1 GNAT family N-acetyltransferase -
LIS66_RS10320 (LIS66_10320) 2329046..2329735 - 690 WP_227974180.1 N-acetyltransferase -
LIS66_RS10325 (LIS66_10325) 2329797..2331716 - 1920 WP_042609487.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(25-89)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10662.26 Da        Isoelectric Point: 10.9839

>T222229 WP_042609483.1 NZ_CP085885:c2326934-2326641 [Pseudomonas sp. HN2]
MTYLIQQTAIFHAWHRSIRDLRAKVAIARRIDRASTGNLGDAKSVGDGVSEMRLDVGAGYRVYFTIRNGAVIILLAGGDK
SSQSADIRRAQKMAKEV

Download         Length: 294 bp

>T222229 NZ_CP117726:1050-1298 [Enterobacter asburiae]
ATGGGGAAAACAGATAAGCTACTGGCAAAGTTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTGGTCGTTTTGTT
TTCCTCTTTGGGATATGTCAAAAAGGAAATGCAGGGGTCAAGAGTGCGGTTTTTCAATGCTGAAATCAATCACACCATAT
TAATGCATCGTCCACATCCGGAAAGTTATATCAAAGGTGGTACGCTGAAAGCAATTAAACAGAATCTGAAAGAGGCTGGA
TTATTATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11086.63 Da        Isoelectric Point: 5.5656

>AT222229 WP_042609482.1 NZ_CP085885:c2326638-2326330 [Pseudomonas sp. HN2]
MSQTLTNFDMVALLDSDEAISEYLSQVLADGDSEEFLRAIGYVLRARGMTQIAKNSGMGRESLYKAFAPGAKPRFDTVLK
VIHALGIDLYAQPGHVVNHAAT

Download         Length: 309 bp

>AT222229 NZ_CP117726:1295-1642 [Enterobacter asburiae]
ATGAAACATTTAAAATATAAAGGATATTTAGGCACGGTTGAACCCGATTTTGAAAATAATGTCCTGTATGGAAAACTGGC
GTTTATTCGGGACCTGGTAACTTATGAGGCTTCTACATTAGCTGAACTGGAACAGGAGTTTAAAACATCTGTTGATCTGT
ATTTACAGTCTTGTGTGGAGGATGGAAAGGAACCTGATACCCCGTTTAAAGGCGTGTTTAACGTCAGGCTTGATCCAGAA
CTGCATCGTCGGGTAGCAGAAATGGCGATGGAAGAAGATTTATCGTTGAATGCCTTTGTTAATAAGGCTCTGGAAAAAGA
AGTCAGCAATCATCGCGCAGGGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References