22222

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1942258..1942871 Replicon chromosome
Accession NC_009565
Organism Mycobacterium tuberculosis F11

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag TBFG_RS09025 Protein ID WP_003408465.1
Coordinates 1942258..1942647 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag TBFG_RS09030 Protein ID WP_003408469.1
Coordinates 1942644..1942871 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBFG_RS08990 1937888..1938802 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
TBFG_RS08995 1938805..1939635 + 831 WP_003906661.1 cyclase family protein -
TBFG_RS09000 1939635..1939984 + 350 Protein_1762 cupin domain-containing protein -
TBFG_RS09005 1940037..1940855 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
TBFG_RS09010 1940869..1941648 + 780 WP_003408460.1 IclR family transcriptional regulator -
TBFG_RS09025 1942258..1942647 - 390 WP_003408465.1 PIN domain-containing protein Toxin
TBFG_RS09030 1942644..1942871 - 228 WP_003408469.1 antitoxin Antitoxin
TBFG_RS09035 1943089..1944573 + 1485 WP_009937637.1 biotin carboxylase -
TBFG_RS09040 1944570..1945817 + 1248 WP_003408476.1 serine hydrolase -
TBFG_RS09055 1947347..1947637 - 291 Protein_1770 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T22222 WP_003408465.1 NC_009565:c1942647-1942258 [Mycobacterium tuberculosis F11]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T22222 NC_009565:c1942647-1942258 [Mycobacterium tuberculosis F11]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT22222 WP_003408469.1 NC_009565:c1942871-1942644 [Mycobacterium tuberculosis F11]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT22222 NC_009565:c1942871-1942644 [Mycobacterium tuberculosis F11]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAN9

References