Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4660744..4661554 Replicon chromosome
Accession NZ_CP085866
Organism Klebsiella pneumoniae strain MV-u1-SK2-O

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag LKZ97_RS22940 Protein ID WP_048337996.1
Coordinates 4660744..4661277 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag LKZ97_RS22945 Protein ID WP_002887278.1
Coordinates 4661288..4661554 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKZ97_RS22935 (LKZ97_22980) 4659575..4660696 + 1122 WP_004214138.1 cupin domain-containing protein -
LKZ97_RS22940 (LKZ97_22985) 4660744..4661277 - 534 WP_048337996.1 type II toxin-antitoxin system toxin KacT Toxin
LKZ97_RS22945 (LKZ97_22990) 4661288..4661554 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
LKZ97_RS22950 (LKZ97_22995) 4661657..4663090 - 1434 WP_044245276.1 Cu(+)/Ag(+) sensor histidine kinase -
LKZ97_RS22955 (LKZ97_23000) 4663080..4663763 - 684 WP_032105399.1 copper response regulator transcription factor CusR -
LKZ97_RS22960 (LKZ97_23005) 4663935..4665320 + 1386 WP_048337995.1 efflux transporter outer membrane subunit -
LKZ97_RS22965 (LKZ97_23010) 4665338..4665682 + 345 WP_021462623.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19824.68 Da        Isoelectric Point: 5.2614

>T222219 WP_048337996.1 NZ_CP085866:c4661277-4660744 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSLQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T222219 NZ_CP117723:c2798946-2798843 [Enterobacter asburiae]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT222219 WP_002887278.1 NZ_CP085866:c4661554-4661288 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT222219 NZ_CP117723:2798837-2798981 [Enterobacter asburiae]
ACAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References