Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4717908..4718424 Replicon chromosome
Accession NZ_CP085863
Organism Klebsiella pneumoniae strain MV-v4-SK2-O

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag LKZ99_RS23135 Protein ID WP_009309309.1
Coordinates 4717908..4718192 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LKZ99_RS23140 Protein ID WP_002886901.1
Coordinates 4718182..4718424 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKZ99_RS23110 (LKZ99_23170) 4713383..4713646 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LKZ99_RS23115 (LKZ99_23175) 4713776..4713949 + 174 WP_002886906.1 hypothetical protein -
LKZ99_RS23120 (LKZ99_23180) 4713952..4714695 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LKZ99_RS23125 (LKZ99_23185) 4715052..4717190 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LKZ99_RS23130 (LKZ99_23190) 4717440..4717904 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LKZ99_RS23135 (LKZ99_23195) 4717908..4718192 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LKZ99_RS23140 (LKZ99_23200) 4718182..4718424 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LKZ99_RS23145 (LKZ99_23205) 4718502..4720412 - 1911 WP_004152270.1 PRD domain-containing protein -
LKZ99_RS23150 (LKZ99_23210) 4720435..4721589 - 1155 WP_002886900.1 lactonase family protein -
LKZ99_RS23155 (LKZ99_23215) 4721656..4722396 - 741 WP_060175498.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T222203 WP_009309309.1 NZ_CP085863:c4718192-4717908 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T222203 NZ_CP117720:3553745-3553963 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT222203 WP_002886901.1 NZ_CP085863:c4718424-4718182 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT222203 NZ_CP117720:3553345-3553719 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References