22220

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1690908..1691524 Replicon chromosome
Accession NC_009565
Organism Mycobacterium tuberculosis F11

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag TBFG_RS07940 Protein ID WP_003407593.1
Coordinates 1691207..1691524 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag TBFG_RS07935 Protein ID WP_003900349.1
Coordinates 1690908..1691210 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBFG_RS07925 1686794..1688641 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
TBFG_RS07930 1688642..1690894 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
TBFG_RS07935 1690908..1691210 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
TBFG_RS07940 1691207..1691524 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
TBFG_RS07945 1691521..1692525 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
TBFG_RS07950 1692578..1693867 + 1290 WP_003407599.1 serine hydrolase -
TBFG_RS07955 1693940..1694713 - 774 WP_003912632.1 class I SAM-dependent methyltransferase -
TBFG_RS07960 1694771..1694983 - 213 WP_003898900.1 dodecin family protein -
TBFG_RS22415 1694993..1695217 - 225 WP_160522526.1 NUDIX domain-containing protein -
TBFG_RS07970 1695487..1696515 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T22220 WP_003407593.1 NC_009565:1691207-1691524 [Mycobacterium tuberculosis F11]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T22220 NC_009565:1691207-1691524 [Mycobacterium tuberculosis F11]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT22220 WP_003900349.1 NC_009565:1690908-1691210 [Mycobacterium tuberculosis F11]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT22220 NC_009565:1690908-1691210 [Mycobacterium tuberculosis F11]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
AlphaFold DB G0TJ73

References