Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH
Location 4215113..4215836 Replicon chromosome
Accession NZ_CP085860
Organism Serratia marcescens strain MV-u1-SK1-O

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LKZ96_RS20125 Protein ID WP_049296187.1
Coordinates 4215113..4215499 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LKZ96_RS20130 Protein ID WP_025304117.1
Coordinates 4215492..4215836 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKZ96_RS20115 (LKZ96_20140) 4212226..4213743 - 1518 WP_004931697.1 lysine--tRNA ligase -
LKZ96_RS20125 (LKZ96_20150) 4215113..4215499 + 387 WP_049296187.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LKZ96_RS20130 (LKZ96_20155) 4215492..4215836 + 345 WP_025304117.1 helix-turn-helix domain-containing protein Antitoxin
LKZ96_RS20135 (LKZ96_20160) 4215887..4217620 - 1734 WP_016929971.1 single-stranded-DNA-specific exonuclease RecJ -
LKZ96_RS20140 (LKZ96_20165) 4217627..4218343 - 717 WP_025304118.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LKZ96_RS20145 (LKZ96_20170) 4218370..4219290 - 921 WP_154747450.1 site-specific tyrosine recombinase XerD -
LKZ96_RS20150 (LKZ96_20175) 4219376..4219894 + 519 WP_025304119.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(54-91)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14614.65 Da        Isoelectric Point: 9.4235

>T222187 WP_049296187.1 NZ_CP085860:4215113-4215499 [Serratia marcescens]
MDIFVTDDFDKFMKKNRIVDQKICTAAHELAHGNHDGDLGGGVYKKRISLNRGKRGGARSIVAFKRGRHQYFIDGWLKNT
VKQNGAKEINDDELATYRELARDFLAMPPEIIKRAIDSGYLREVKCDD

Download         Length: 387 bp

>T222187 NZ_CP117718:48955-49104 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12919.85 Da        Isoelectric Point: 11.4121

>AT222187 WP_025304117.1 NZ_CP085860:4215492-4215836 [Serratia marcescens]
MTDNRLLRLQKMAQRFNEIGAVSDDTVRNIATRVQAQEQHAQREQHDQMDGARIKMLRRRLGLSQADLAAVVNMSTTSVQ
KWERNAVKPQGAALRMLEIIEQKGVASLIISPRN

Download         Length: 345 bp

>AT222187 NZ_CP117718:c48911-48850 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References