Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3734129..3734691 Replicon chromosome
Accession NZ_CP085860
Organism Serratia marcescens strain MV-u1-SK1-O

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag LKZ96_RS17860 Protein ID WP_025303801.1
Coordinates 3734129..3734485 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag LKZ96_RS17865 Protein ID WP_004936539.1
Coordinates 3734482..3734691 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKZ96_RS17840 (LKZ96_17860) 3729865..3730662 - 798 WP_025303797.1 TonB family protein -
LKZ96_RS17845 (LKZ96_17865) 3730765..3731604 - 840 WP_025303798.1 ChaN family lipoprotein -
LKZ96_RS17850 (LKZ96_17870) 3731782..3733191 + 1410 WP_049205384.1 S-methylmethionine permease -
LKZ96_RS17855 (LKZ96_17875) 3733181..3734119 + 939 WP_089181192.1 homocysteine S-methyltransferase -
LKZ96_RS17860 (LKZ96_17880) 3734129..3734485 - 357 WP_025303801.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LKZ96_RS17865 (LKZ96_17885) 3734482..3734691 - 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LKZ96_RS17870 (LKZ96_17890) 3734801..3737080 - 2280 WP_016926766.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
LKZ96_RS17875 (LKZ96_17895) 3737296..3737469 - 174 WP_049205380.1 hypothetical protein -
LKZ96_RS17880 (LKZ96_17900) 3737450..3737830 - 381 WP_025303802.1 DUF2570 family protein -
LKZ96_RS17885 (LKZ96_17905) 3737827..3738228 - 402 WP_015378690.1 M15 family metallopeptidase -
LKZ96_RS17890 (LKZ96_17910) 3738218..3738544 - 327 WP_004936551.1 phage holin, lambda family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3724700..3734691 9991


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(27-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13163.93 Da        Isoelectric Point: 4.9139

>T222184 WP_025303801.1 NZ_CP085860:c3734485-3734129 [Serratia marcescens]
MIFLTAEDIAEFNAEIVPHGRQEGSKVEAVANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRRLTE

Download         Length: 357 bp

>T222184 NZ_CP117717:c4460787-4460614 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT222184 WP_004936539.1 NZ_CP085860:c3734691-3734482 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT222184 NZ_CP117717:c4461111-4460815 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References