Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1547090..1547637 Replicon chromosome
Accession NZ_CP085860
Organism Serratia marcescens strain MV-u1-SK1-O

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag LKZ96_RS07470 Protein ID WP_049208872.1
Coordinates 1547329..1547637 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag LKZ96_RS07465 Protein ID WP_025302143.1
Coordinates 1547090..1547326 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKZ96_RS07450 (LKZ96_07460) 1543576..1545111 + 1536 WP_089180702.1 glutathione ABC transporter substrate-binding protein GsiB -
LKZ96_RS07455 (LKZ96_07465) 1545164..1546084 + 921 WP_025302141.1 glutathione ABC transporter permease GsiC -
LKZ96_RS07460 (LKZ96_07470) 1546094..1547002 + 909 WP_169540348.1 glutathione ABC transporter permease GsiD -
LKZ96_RS07465 (LKZ96_07475) 1547090..1547326 + 237 WP_025302143.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LKZ96_RS07470 (LKZ96_07480) 1547329..1547637 + 309 WP_049208872.1 CcdB family protein Toxin
LKZ96_RS07475 (LKZ96_07485) 1547677..1548519 - 843 WP_015377214.1 S-formylglutathione hydrolase -
LKZ96_RS07480 (LKZ96_07490) 1548534..1549658 - 1125 WP_043142415.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
LKZ96_RS07485 (LKZ96_07495) 1549689..1550609 - 921 WP_089180703.1 LysR family transcriptional regulator -
LKZ96_RS07490 (LKZ96_07500) 1550715..1551872 + 1158 WP_043142422.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11518.35 Da        Isoelectric Point: 5.0196

>T222174 WP_049208872.1 NZ_CP085860:1547329-1547637 [Serratia marcescens]
MQFTVYDNTYPASAYPYLLDVQSDLIDVLSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAIRISQIGKA
VGNVNEHRNQIKAAIDFLIDGF

Download         Length: 309 bp

>T222174 NZ_CP117717:1866244-1866495 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8967.04 Da        Isoelectric Point: 5.0807

>AT222174 WP_025302143.1 NZ_CP085860:1547090-1547326 [Serratia marcescens]
MANSNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp

>AT222174 NZ_CP117717:1866492-1866746 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References