Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 532353..533976 Replicon chromosome
Accession NZ_CP085860
Organism Serratia marcescens strain MV-u1-SK1-O

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LKZ96_RS02450 Protein ID WP_089181609.1
Coordinates 532654..533976 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LKZ96_RS02445 Protein ID WP_089181608.1
Coordinates 532353..532649 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LKZ96_RS02420 (LKZ96_02425) 527467..527859 - 393 WP_043136290.1 VOC family protein -
LKZ96_RS02425 (LKZ96_02430) 527861..529192 - 1332 WP_049271155.1 L-fucose:H+ symporter permease -
LKZ96_RS02430 (LKZ96_02435) 529189..530718 - 1530 WP_049294761.1 FGGY family carbohydrate kinase -
LKZ96_RS02435 (LKZ96_02440) 530784..531533 - 750 WP_043136281.1 deoxyribose-phosphate aldolase -
LKZ96_RS02445 (LKZ96_02450) 532353..532649 + 297 WP_089181608.1 helix-turn-helix transcriptional regulator Antitoxin
LKZ96_RS02450 (LKZ96_02455) 532654..533976 + 1323 WP_089181609.1 type II toxin-antitoxin system HipA family toxin Toxin
LKZ96_RS02455 (LKZ96_02460) 534191..537796 - 3606 WP_217429012.1 AAA domain-containing protein -
LKZ96_RS02460 (LKZ96_02465) 538037..538216 + 180 Protein_462 IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-68)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49838.92 Da        Isoelectric Point: 6.2359

>T222171 WP_089181609.1 NZ_CP085860:532654-533976 [Serratia marcescens]
MRRSQQRLAIWMNGIPVGYWEKRKGEDRLEYLPEWIADSQGRPLSLSLPFTPGNQPYRGSVVRDYFDNLLPDSEGIRRRL
AMRYHADSLDPFDLLAELGRDCVGAIQLLDIGEQPADIFSIRQRPLAEAQIAEMLRNTATTLPGLQGQDDDLRLSIAGAQ
EKTALLWHDNQWCLPEGNTPTTHIFKLALGLVGNMRADMRTSIENEWLCSMIVEHYGVPVASTHIAQFEDQKALIVERFD
RKLSSDKQWWIRLPQEDMCQALGVSPLRKYQSDGGPGITDIMEILSRSEQAETDRRHFFKAQIIFWLLAATDGHAKNFSL
AHLPQNRYHLTPLYDVLSAWPLIGPGNNQIAWQKCKLAMAVRGSSNHYLLSQIRRRHWIKHGEITGLGQQEVESIIEELL
AATPGVIDCVIGLLPDSFPAELAECIFDGIRQQCARLAGR

Download         Length: 1323 bp

>T222171 NZ_CP117717:913652-914059 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGTTTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11021.61 Da        Isoelectric Point: 8.0100

>AT222171 WP_089181608.1 NZ_CP085860:532353-532649 [Serratia marcescens]
MNTVYPLKTLSQLRPLLVGFRKAKGLTQKDVSERLGVTQQTYARLESNPASASLERLFRVFNVLGIEIVFSSELASPGCE
TEEISTIHIDSPARREQW

Download         Length: 297 bp

>AT222171 NZ_CP117717:913405-913671 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References