Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 37759..38498 Replicon plasmid pLH214-1
Accession NZ_CP085859
Organism Vibrio parahaemolyticus strain LH214

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag JK088_RS24650 Protein ID WP_248212935.1
Coordinates 38013..38498 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag JK088_RS24645 Protein ID WP_268206415.1
Coordinates 37759..38025 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JK088_RS24615 (JK088_24600) 33077..33238 - 162 WP_268206410.1 hypothetical protein -
JK088_RS24620 (JK088_24605) 33461..34819 - 1359 WP_268206411.1 EAL domain-containing protein -
JK088_RS24625 (JK088_24610) 35030..35449 - 420 WP_268206412.1 ASCH domain-containing protein -
JK088_RS24630 (JK088_24615) 35690..36046 - 357 WP_268206413.1 DUF4440 domain-containing protein -
JK088_RS24635 (JK088_24620) 36292..36957 - 666 WP_268206414.1 AbiV family abortive infection protein -
JK088_RS24640 (JK088_24625) 37026..37277 - 252 Protein_49 transposase -
JK088_RS24645 (JK088_24630) 37759..38025 + 267 WP_268206415.1 DUF1778 domain-containing protein Antitoxin
JK088_RS24650 (JK088_24635) 38013..38498 + 486 WP_248212935.1 GNAT family N-acetyltransferase Toxin
JK088_RS24655 (JK088_24640) 38689..38944 + 256 Protein_52 helix-turn-helix domain-containing protein -
JK088_RS24660 (JK088_24645) 39125..39496 + 372 WP_049134827.1 hypothetical protein -
JK088_RS24665 (JK088_24650) 39780..42008 - 2229 WP_268206416.1 Mov34/MPN/PAD-1 family protein -
JK088_RS24670 (JK088_24655) 42008..43183 - 1176 WP_268206417.1 metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..89676 89676
- flank IS/Tn - - 37026..37154 128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(34-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17638.33 Da        Isoelectric Point: 9.1045

>T222169 WP_248212935.1 NZ_CP085859:38013-38498 [Vibrio parahaemolyticus]
VGPVTAPEPLSSSHQLAEFVSGEVVLDDWLKQRGLKNQALGAARTFVVCKTDTKQVVGFYSLATGSVNHVEATGSLRRNM
PDPIPVIILARLAVDFSFRGQGLGADLLHDAVLRCYRVADNIGVRAIMVHALTEEAKNFYLHHGFKASKTQERTLFLKLP
Q

Download         Length: 486 bp

>T222169 NZ_CP117717:269191-269466 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATAGTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10093.50 Da        Isoelectric Point: 4.4733

>AT222169 WP_268206415.1 NZ_CP085859:37759-38025 [Vibrio parahaemolyticus]
MKSDVQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVTDDAAINKLL
ARKPQWDL

Download         Length: 267 bp

>AT222169 NZ_CP117717:269463-269822 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References