Detailed information of TA system TA222167

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 2007313..2007851
• Replicon: chromosome
• Accession: NZ_CP085857
• Organism: Vibrio parahaemolyticus strain LH214

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: JK088_RS09615
• Protein ID: WP_017449644.1
• Coordinates: 2007552..2007851 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: JK088_RS09610
• Protein ID: WP_017449645.1
• Coordinates: 2007313..2007555 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JK088_RS09570 (JK088_09575)	2002605..2002682	-	78	WP_080100249.1	DUF3265 domain-containing protein	-
JK088_RS09575 (JK088_09580)	2003093..2003185	-	93	WP_079379419.1	DUF3265 domain-containing protein	-
JK088_RS09580 (JK088_09585)	2003515..2003604	-	90	WP_071652537.1	DUF3265 domain-containing protein	-
JK088_RS09585 (JK088_09590)	2004122..2004211	-	90	WP_072828858.1	DUF3265 domain-containing protein	-
JK088_RS09590	2004618..2004668	-	51	WP_229651985.1	hypothetical protein	-
JK088_RS09595 (JK088_09600)	2005556..2005633	-	78	WP_080100252.1	DUF3265 domain-containing protein	-
JK088_RS09600 (JK088_09605)	2005673..2005978	-	306	WP_229634388.1	GFA family protein	-
JK088_RS09605 (JK088_09610)	2006248..2007108	-	861	WP_017449634.1	restriction endonuclease	-
JK088_RS09610 (JK088_09615)	2007313..2007555	+	243	WP_017449645.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
JK088_RS09615 (JK088_09620)	2007552..2007851	+	300	WP_017449644.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JK088_RS09620 (JK088_09630)	2007956..2008231	-	276	WP_017449630.1	DUF5071 domain-containing protein	-
JK088_RS09625 (JK088_09635)	2008379..2008519	-	141	WP_100224986.1	DUF3265 domain-containing protein	-
JK088_RS09630 (JK088_09640)	2008497..2008781	-	285	WP_017449629.1	MazG nucleotide pyrophosphohydrolase domain-containing protein	-
JK088_RS09635 (JK088_09645)	2008932..2009342	-	411	WP_017449628.1	hypothetical protein	-
JK088_RS09640 (JK088_09650)	2009525..2010382	-	858	WP_005472288.1	hypothetical protein	-
JK088_RS09645 (JK088_09655)	2010487..2010564	-	78	Protein_1873	DUF3265 domain-containing protein	-
JK088_RS09650 (JK088_09660)	2010910..2011035	-	126	WP_080100246.1	DUF3265 domain-containing protein	-
JK088_RS09655 (JK088_09665)	2011377..2011511	-	135	WP_164842021.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1902315..2043068	140753

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11733.42 Da
• Isoelectric Point: 9.9572

>T222167 WP_017449644.1 NZ_CP085857:2007552-2007851 [Vibrio parahaemolyticus]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDSYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPIFGA

Nucleotide

• Length: 300 bp

>T222167 NZ_CP117716:44511-44660 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8967.95 Da
• Isoelectric Point: 4.3440

>AT222167 WP_017449645.1 NZ_CP085857:2007313-2007555 [Vibrio parahaemolyticus]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFIKELDSEERK

Nucleotide

• Length: 243 bp

>AT222167 NZ_CP117716:c44467-44406 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT