Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 1992262..1992800 | Replicon | chromosome |
| Accession | NZ_CP085857 | ||
| Organism | Vibrio parahaemolyticus strain LH214 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | JK088_RS09465 | Protein ID | WP_017449644.1 |
| Coordinates | 1992501..1992800 (+) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | - |
| Locus tag | JK088_RS09460 | Protein ID | WP_017449645.1 |
| Coordinates | 1992262..1992504 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JK088_RS09430 (JK088_09435) | 1987808..1988152 | - | 345 | WP_017449602.1 | hypothetical protein | - |
| JK088_RS09435 (JK088_09440) | 1988375..1989295 | + | 921 | WP_010446562.1 | IS5-like element ISVa2 family transposase | - |
| JK088_RS09440 (JK088_09445) | 1989384..1989770 | - | 387 | WP_025983450.1 | NUDIX hydrolase | - |
| JK088_RS09445 (JK088_09450) | 1989920..1990369 | - | 450 | WP_017449604.1 | hypothetical protein | - |
| JK088_RS09450 (JK088_09455) | 1990561..1990980 | - | 420 | WP_017449605.1 | hypothetical protein | - |
| JK088_RS09455 (JK088_09460) | 1991136..1991585 | - | 450 | WP_017449606.1 | GNAT family N-acetyltransferase | - |
| JK088_RS09460 (JK088_09465) | 1992262..1992504 | + | 243 | WP_017449645.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| JK088_RS09465 (JK088_09470) | 1992501..1992800 | + | 300 | WP_017449644.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JK088_RS09470 (JK088_09475) | 1992808..1992897 | - | 90 | WP_074531745.1 | DUF3265 domain-containing protein | - |
| JK088_RS09475 (JK088_09480) | 1992929..1993297 | - | 369 | WP_017449638.1 | VOC family protein | - |
| JK088_RS09480 (JK088_09485) | 1993327..1993443 | - | 117 | WP_100224987.1 | DUF3265 domain-containing protein | - |
| JK088_RS09485 (JK088_09490) | 1993434..1994207 | - | 774 | WP_017449639.1 | hypothetical protein | - |
| JK088_RS09490 (JK088_09495) | 1994342..1994722 | - | 381 | WP_025983451.1 | glyoxalase | - |
| JK088_RS09495 (JK088_09500) | 1994880..1995350 | - | 471 | WP_017449646.1 | hypothetical protein | - |
| JK088_RS09500 (JK088_09505) | 1995411..1995500 | - | 90 | WP_074190212.1 | DUF3265 domain-containing protein | - |
| JK088_RS09505 (JK088_09510) | 1996021..1996161 | - | 141 | WP_161607541.1 | DUF3265 domain-containing protein | - |
| JK088_RS09510 (JK088_09515) | 1996545..1996940 | - | 396 | WP_017449623.1 | ACT domain-containing protein | - |
| JK088_RS09515 (JK088_09520) | 1996973..1997050 | - | 78 | WP_229651823.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1988375..1989295 | 920 | |
| - | inside | Integron | - | - | 1902315..2043068 | 140753 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11733.42 Da Isoelectric Point: 9.9572
>T222166 WP_017449644.1 NZ_CP085857:1992501-1992800 [Vibrio parahaemolyticus]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDSYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPIFGA
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDSYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPIFGA
Download Length: 300 bp
>T222166 NZ_CP117716:c35555-35157 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8967.95 Da Isoelectric Point: 4.3440
>AT222166 WP_017449645.1 NZ_CP085857:1992262-1992504 [Vibrio parahaemolyticus]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFIKELDSEERK
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFIKELDSEERK
Download Length: 243 bp
>AT222166 NZ_CP117716:c35782-35555 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|