Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 1914318..1914856 | Replicon | chromosome |
| Accession | NZ_CP085857 | ||
| Organism | Vibrio parahaemolyticus strain LH214 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | JK088_RS08750 | Protein ID | WP_017449644.1 |
| Coordinates | 1914557..1914856 (+) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | - |
| Locus tag | JK088_RS08745 | Protein ID | WP_017449645.1 |
| Coordinates | 1914318..1914560 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JK088_RS08715 (JK088_08715) | 1909328..1909795 | - | 468 | WP_017448866.1 | NUDIX domain-containing protein | - |
| JK088_RS08720 (JK088_08720) | 1909823..1909900 | - | 78 | WP_080100209.1 | DUF3265 domain-containing protein | - |
| JK088_RS08725 (JK088_08725) | 1909929..1910411 | - | 483 | WP_017448865.1 | hypothetical protein | - |
| JK088_RS08730 (JK088_08730) | 1910574..1911482 | - | 909 | WP_017448864.1 | hypothetical protein | - |
| JK088_RS08735 (JK088_08735) | 1912524..1912616 | - | 93 | WP_071652217.1 | DUF3265 domain-containing protein | - |
| JK088_RS08740 (JK088_08740) | 1912641..1913063 | - | 423 | WP_017448861.1 | hypothetical protein | - |
| JK088_RS08745 (JK088_08745) | 1914318..1914560 | + | 243 | WP_017449645.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| JK088_RS08750 (JK088_08750) | 1914557..1914856 | + | 300 | WP_017449644.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JK088_RS08755 (JK088_08755) | 1914986..1915741 | - | 756 | WP_017449635.1 | DUF3944 domain-containing protein | - |
| JK088_RS08760 (JK088_08760) | 1915788..1915922 | - | 135 | WP_229643081.1 | DUF3265 domain-containing protein | - |
| JK088_RS08765 (JK088_08765) | 1915918..1916472 | - | 555 | WP_017449636.1 | hypothetical protein | - |
| JK088_RS08770 (JK088_08770) | 1916495..1916587 | - | 93 | WP_079748754.1 | DUF3265 domain-containing protein | - |
| JK088_RS08775 (JK088_08775) | 1916602..1917036 | - | 435 | WP_031858805.1 | hypothetical protein | - |
| JK088_RS08780 (JK088_08780) | 1917142..1917210 | - | 69 | Protein_1700 | DUF3265 domain-containing protein | - |
| JK088_RS08785 (JK088_08785) | 1917195..1917671 | - | 477 | WP_017449647.1 | GNAT family N-acetyltransferase | - |
| JK088_RS08790 (JK088_08790) | 1917815..1918309 | - | 495 | WP_017449579.1 | GNAT family N-acetyltransferase | - |
| JK088_RS08795 (JK088_08795) | 1918342..1918434 | - | 93 | WP_080100239.1 | DUF3265 domain-containing protein | - |
| JK088_RS08800 (JK088_08800) | 1918477..1919064 | - | 588 | WP_017449594.1 | hypothetical protein | - |
| JK088_RS08805 (JK088_08805) | 1919572..1919694 | - | 123 | WP_079770955.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 1902315..2043068 | 140753 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11733.42 Da Isoelectric Point: 9.9572
>T222163 WP_017449644.1 NZ_CP085857:1914557-1914856 [Vibrio parahaemolyticus]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDSYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPIFGA
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDSYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPIFGA
Download Length: 300 bp
>T222163 NZ_CP117714:c4365124-4364951 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8967.95 Da Isoelectric Point: 4.3440
>AT222163 WP_017449645.1 NZ_CP085857:1914318-1914560 [Vibrio parahaemolyticus]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFIKELDSEERK
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFIKELDSEERK
Download Length: 243 bp
>AT222163 NZ_CP117714:c4365448-4365152 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CTTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CTTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|