Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 61482..62010 Replicon plasmid pNV27-261K
Accession NZ_CP085845
Organism Vibrio diabolicus strain NV27

Toxin (Protein)


Gene name relE Uniprot ID A0A1W6UUU0
Locus tag LJY22_RS23135 Protein ID WP_025767362.1
Coordinates 61726..62010 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7H8DZ36
Locus tag LJY22_RS23130 Protein ID WP_025767361.1
Coordinates 61482..61736 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJY22_RS23090 (LJY22_23075) 56815..57189 - 375 WP_257898051.1 hypothetical protein -
LJY22_RS23095 (LJY22_23080) 57370..58200 - 831 WP_257898052.1 hypothetical protein -
LJY22_RS23100 (LJY22_23085) 58347..58523 - 177 WP_158501046.1 hypothetical protein -
LJY22_RS23105 (LJY22_23090) 58534..59127 - 594 WP_025767356.1 hypothetical protein -
LJY22_RS23110 (LJY22_23095) 59338..59676 + 339 WP_025767357.1 hypothetical protein -
LJY22_RS23115 (LJY22_23100) 59725..59958 - 234 WP_025767358.1 hypothetical protein -
LJY22_RS23120 (LJY22_23105) 59977..60411 - 435 WP_025767359.1 hypothetical protein -
LJY22_RS23125 (LJY22_23110) 60477..61229 - 753 WP_025767360.1 hypothetical protein -
LJY22_RS23130 (LJY22_23115) 61482..61736 + 255 WP_025767361.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LJY22_RS23135 (LJY22_23120) 61726..62010 + 285 WP_025767362.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJY22_RS23140 (LJY22_23125) 62247..62435 + 189 WP_025767364.1 hypothetical protein -
LJY22_RS23145 (LJY22_23130) 62448..62711 + 264 WP_025767365.1 hypothetical protein -
LJY22_RS23150 (LJY22_23135) 62946..63266 - 321 WP_025767366.1 hypothetical protein -
LJY22_RS23155 (LJY22_23140) 63517..64263 + 747 WP_025767367.1 hypothetical protein -
LJY22_RS23160 (LJY22_23145) 65502..65810 + 309 WP_025767368.1 hypothetical protein -
LJY22_RS23165 (LJY22_23150) 66110..66430 + 321 WP_025767369.1 hypothetical protein -
LJY22_RS23170 (LJY22_23155) 66440..66643 + 204 WP_025767370.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..261992 261992


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11103.10 Da        Isoelectric Point: 10.6691

>T222162 WP_025767362.1 NZ_CP085845:61726-62010 [Vibrio diabolicus]
MTYKLVFKTEAEKEWRKLDSTIKSQFKKKLIERLENPHVPTAKLSSMENCYKIKLRSAGYRLVYQVRDQEVIISVVAVGK
RERNQVYKIAAKRV

Download         Length: 285 bp

>T222162 NZ_CP117714:c4268805-4268455 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9460.78 Da        Isoelectric Point: 3.9953

>AT222162 WP_025767361.1 NZ_CP085845:61482-61736 [Vibrio diabolicus]
MPTIRPILADNSTSISELKKNPMAVIEQADGFPVAVLNRNQPAFYCVPADAYEMLMDKLEDIELAQIVKEREHSEEVEIS
IDDL

Download         Length: 255 bp

>AT222162 NZ_CP117714:c4269050-4268799 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCTTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1W6UUU0

Antitoxin

Source ID Structure
AlphaFold DB A0A7H8DZ36

References