Detailed information of TA system TA222161

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 3039404..3041091
• Replicon: chromosome
• Accession: NZ_CP085843
• Organism: Vibrio diabolicus strain NV27

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: LJY22_RS13985
• Protein ID: WP_069537229.1
• Coordinates: 3039404..3040627 (-)
• Length: 408 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: LJY22_RS13990
• Protein ID: WP_005378671.1
• Coordinates: 3040624..3041091 (-)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJY22_RS13970 (LJY22_13960)	3035083..3035766	-	684	WP_104969913.1	ATPase	-
LJY22_RS13975 (LJY22_13965)	3035827..3037662	-	1836	WP_257897021.1	TonB-dependent vitamin B12 receptor	-
LJY22_RS13980 (LJY22_13970)	3038103..3039212	+	1110	WP_253644873.1	tRNA (uridine(54)-C5)-methyltransferase TrmA	-
LJY22_RS13985 (LJY22_13975)	3039404..3040627	-	1224	WP_069537229.1	RelA/SpoT domain-containing protein	Toxin
LJY22_RS13990 (LJY22_13980)	3040624..3041091	-	468	WP_005378671.1	DUF4065 domain-containing protein	Antitoxin
LJY22_RS13995 (LJY22_13985)	3041420..3042091	-	672	WP_064376998.1	hypothetical protein	-
LJY22_RS14000 (LJY22_13990)	3042236..3043252	+	1017	WP_257897022.1	hypothetical protein	-
LJY22_RS14005 (LJY22_13995)	3043435..3044079	+	645	WP_182016973.1	inovirus Gp2 family protein	-
LJY22_RS14010 (LJY22_14000)	3044120..3044566	-	447	WP_257897023.1	hypothetical protein	-
LJY22_RS14015 (LJY22_14005)	3044676..3045665	-	990	WP_257897024.1	50S ribosome-binding GTPase	-
LJY22_RS14020 (LJY22_14010)	3045743..3045952	+	210	WP_104969920.1	AlpA family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RelA/SpoT (111-228)

Antitoxin

• Antitoxin SocA-like, Panacea domain (32-123)

Sequences

Toxin

Protein

• Length: 408 a.a.
• Molecular weight: 45879.64 Da
• Isoelectric Point: 5.3831

>T222161 WP_069537229.1 NZ_CP085843:c3040627-3039404 [Vibrio diabolicus]
VSNKENSVVSFYIDDTPTAEQASKTFQDDYELDFQDFIERTVNESAAEDFSYSNNGVKKAGRRLRKREGDLKSATATIQQ
FRAAHEKPLNTIAYLVGRCCRELGIDVKPVTRLKRLETIVDKLQRKSLDGETANATCVTNMNDIGGCRAIFPDLISLEKV
KSQLQLTVEKVGRVRIKDIDDYITSPKPNDCGYRSLHVIYRYDHASGKSFNIEAQLRTRLQHLWATTVEIVDILEGTKIK
THSHSSNEGKSSLQVQWEELLSIMSQYIADAEGAIELSDIDKADFSKRLVVLDREINALNRLSSFKILSEKVNSYCDSSI
EHVLLVINETSRELIFSEEFENYSQAISVYNAAEKVTRSYSRATSRLNTLLISTKNMGQLSEAYPNYLGDCASFITLLED
AMLSGES

Nucleotide

• Length: 1224 bp

>T222161 NZ_CP117714:c4193354-4192983 [Escherichia coli]
ATGCAAACTATATCATCACACCCGACACGGGCGACTCAGCCCTGCCTGTCACCCGTTGAAATCTGGCAGCGGTTACTGAC
TTGTCTGTTGTCGCAGCACTATGGTCTGACGTTGAATGACACACCGTTCAGTAATGAAACCACCATACTGGAACACATTG
ATGCTGGAGTATCGCTGTGCGATGCGGTGAACTTTCTTGTTGAAAAATATGAACTGGTAAGAATTGACTGTAATGATTGC
TCTGTCATGGAGAAGTCACCGTTCATCACCAGTATCGATATTCTACGTGCCCGGAAAGCCTCCGGTCTGATGAAACGCAA
CAGTCACAAAACTGTTACCAGGGTAACGGCAGGTCGACTTCAGGAGCTATAA

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17516.97 Da
• Isoelectric Point: 7.9061

>AT222161 WP_005378671.1 NZ_CP085843:c3041091-3040624 [Vibrio diabolicus]
MKAYHTYSAVDVAWSLLKHAKEQGKCFSNLQLQKLTYVCHGLSLAHFQRPLVVDDVFAWKFGPVVPSVYFRFKSYGSSVI
TEQCDVALDQESESIVKDVVSKLGHLTGPQLVDLTHREGSPWHQVWDGTHQKVIPDHLIQAHYTQIKQSGRTASL

Nucleotide

• Length: 468 bp

>AT222161 NZ_CP117714:c4193758-4193393 [Escherichia coli]
ATGAACAATCACTCAGAATCCGGTACAAAGCCGGAGAATCCCGCCTGCCAGCAGTGGGGGCTTAAATGTGCTATTACCCC
CTGTTTTGGTGCCCGCCTGGTACAGGAGGGCAACCGATTGCATTTTCTCTCTGACCGCGCAGGATTTAGCGGGGCATTTG
CCGTCGATGTTGCAATGCGCCTTGACCAGGCATTTCCGTTAATGATGAAGCAACTTGAGCTGATGCTGACCAGTGGAGAG
CTTAACCCTCGCCACCCACACTGCGTCACGCTTTACCACAATGGACTCACCTGTGAAGCCGATACACTAGGCTCCTGTGG
TTATGTCTACATTGCTATCTATCCTGAGCAAACTGAGCCGCAGTAA