Detailed information of TA system TA022216

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1388044..1388732
• Replicon: chromosome
• Accession: NC_009565
• Organism: Mycobacterium tuberculosis F11

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: TBFG_RS06580
• Protein ID: WP_003406304.1
• Coordinates: 1388301..1388732 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: TBFG_RS06575
• Protein ID: WP_003406302.1
• Coordinates: 1388044..1388304 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TBFG_RS06555	1383621..1384445	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
TBFG_RS06560	1384450..1385631	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
TBFG_RS06565	1385708..1386808	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
TBFG_RS06570	1386979..1387968	+	990	WP_012054265.1	malate dehydrogenase	-
TBFG_RS06575	1388044..1388304	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
TBFG_RS06580	1388301..1388732	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
TBFG_RS06590	1388755..1390444	-	1690	Protein_1287	PE family protein	-
TBFG_RS06595	1390624..1391484	+	861	WP_003900301.1	hypothetical protein	-
TBFG_RS06600	1391565..1392395	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
TBFG_RS06605	1392452..1392745	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
TBFG_RS06610	1392742..1393011	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T22216 WP_003406304.1 NC_009565:1388301-1388732 [Mycobacterium tuberculosis F11]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T22216 NC_009565:1388301-1388732 [Mycobacterium tuberculosis F11]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT22216 WP_003406302.1 NC_009565:1388044-1388304 [Mycobacterium tuberculosis F11]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT22216 NC_009565:1388044-1388304 [Mycobacterium tuberculosis F11]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6