Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1462691..1463329 Replicon chromosome
Accession NZ_CP085842
Organism Escherichia coli strain B95. delta A

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag LJ838_RS07320 Protein ID WP_000813794.1
Coordinates 1462691..1462867 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LJ838_RS07325 Protein ID WP_001270286.1
Coordinates 1462913..1463329 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJ838_RS07300 (1458310) 1458310..1459524 - 1215 WP_001326689.1 BenE family transporter YdcO -
LJ838_RS07305 (1459577) 1459577..1460113 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
LJ838_RS07310 (1460186) 1460186..1462147 + 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
LJ838_RS07315 (1462239) 1462239..1462469 - 231 WP_000494244.1 YncJ family protein -
LJ838_RS07320 (1462691) 1462691..1462867 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LJ838_RS07325 (1462913) 1462913..1463329 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LJ838_RS07330 (1463408) 1463408..1464814 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
LJ838_RS07335 (1465059) 1465059..1466204 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
LJ838_RS07340 (1466222) 1466222..1467235 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
LJ838_RS07345 (1467236) 1467236..1468177 + 942 WP_001251313.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T222145 WP_000813794.1 NZ_CP085842:1462691-1462867 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T222145 NZ_CP117714:194360-194467 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT222145 WP_001270286.1 NZ_CP085842:1462913-1463329 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT222145 NZ_CP117714:c194303-194246 [Escherichia coli]
TCAAGATTAGCCCCCGTTATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References