Detailed information of TA system TA222107

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3281705..3282372
• Replicon: chromosome
• Accession: NZ_CP085839
• Organism: Nocardioides sp. Kera G14

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LH076_RS16010
• Protein ID: WP_227781756.1
• Coordinates: 3281705..3282130 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LH076_RS16015
• Protein ID: WP_227781757.1
• Coordinates: 3282127..3282372 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LH076_RS15985 (LH076_15985)	3276814..3278004	-	1191	WP_227781751.1	LCP family protein	-
LH076_RS15990 (LH076_15990)	3278127..3278792	-	666	WP_227781752.1	TetR/AcrR family transcriptional regulator	-
LH076_RS15995 (LH076_15995)	3278876..3279775	+	900	WP_227781753.1	alpha/beta hydrolase	-
LH076_RS16000 (LH076_16000)	3279833..3280684	+	852	WP_227781754.1	SDR family NAD(P)-dependent oxidoreductase	-
LH076_RS16005 (LH076_16005)	3280767..3281672	+	906	WP_227781755.1	alpha/beta hydrolase	-
LH076_RS16010 (LH076_16010)	3281705..3282130	-	426	WP_227781756.1	type II toxin-antitoxin system VapC family toxin	Toxin
LH076_RS16015 (LH076_16015)	3282127..3282372	-	246	WP_227781757.1	hypothetical protein	Antitoxin
LH076_RS16020 (LH076_16020)	3282409..3283698	-	1290	WP_227783654.1	replicative DNA helicase	-
LH076_RS16025 (LH076_16025)	3284178..3285488	+	1311	WP_227781758.1	MATE family efflux transporter	-
LH076_RS16030 (LH076_16030)	3285584..3286036	-	453	WP_227781759.1	50S ribosomal protein L9	-
LH076_RS16035 (LH076_16035)	3286051..3286287	-	237	WP_008355445.1	30S ribosomal protein S18	-
LH076_RS16040 (LH076_16040)	3286367..3286909	-	543	WP_227781760.1	single-stranded DNA-binding protein	-
LH076_RS16045 (LH076_16045)	3286989..3287276	-	288	WP_227781761.1	30S ribosomal protein S6	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-133)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15339.64 Da
• Isoelectric Point: 8.8224

>T222107 WP_227781756.1 NZ_CP085839:c3282130-3281705 [Nocardioides sp. Kera G14]
MKLVDVNVLVYARDSQSPHHRAAKHWLDSALSGSTPVGFSWLVLIGFVRLVTHPRVMASPLTPAEAMATVDAWLAARSAQ
VLHPGQSHARLMAEMLSAVGVGGNLTNDAHLAALALEHRAAIVSFDSDFERFPGVRWEKPR

Nucleotide

• Length: 426 bp

>T222107 NZ_CP117693:3572751-3573026 [Salmonella enterica subsp. enterica serovar London]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGCGACTGGCTGGCAGAAGCGGGATTTGATACCGGGGCGAGCGTGACCGTGAAGAGCTCCGAGGGGTGTT
TGACTCTGATTGCGGAGCGCGACGAGGTGCAGGAGCTGCGGGAGGAACTTTATCAGGTTAAACAGGTGGTTAAAGGAATG
AAGGTCGGGATATCCGGCGTATTACGCGAGGTATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9010.11 Da
• Isoelectric Point: 4.7922

>AT222107 WP_227781757.1 NZ_CP085839:c3282372-3282127 [Nocardioides sp. Kera G14]
VRTTVTLDPDVEQLVRERMAAKGVSFKRALNDAIRESTPRVDYVFETPSSPLGLKIDLEHAGAVLSDLDVDDFLSSAHRD
R

Nucleotide

• Length: 246 bp

>AT222107 NZ_CP117693:c3572975-3572594 [Salmonella enterica subsp. enterica serovar London]
CTGTTTAACCTGATAAAGTTCCTCCCGCAGCTCCTGCACCTCGTCGCGCTCCGCAATCAGAGTCAAACACCCCTCGGAGC
TCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTTCTGCCAGCCAGTCGCCCTTAAGGTGCTGGCTGGGGATTTGT
GAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAAT
AAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGC
GCCTCCCTCTCCCCGGCCAGTACCGGGCGGGGATGAGCAACCGGCTACCGGGGCCGTATTTT