Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4530829..4531610 Replicon chromosome
Accession NZ_CP085824
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Ivysaur

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag LJF36_RS22140 Protein ID WP_000626100.1
Coordinates 4530829..4531320 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LJF36_RS22145 Protein ID WP_001110452.1
Coordinates 4531317..4531610 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF36_RS22105 (4526289) 4526289..4526636 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
LJF36_RS22110 (4526612) 4526612..4528315 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
LJF36_RS22115 (4528352) 4528352..4528927 + 576 WP_001188509.1 transcriptional regulator -
LJF36_RS22125 (4529198) 4529198..4529272 - 75 Protein_4302 helix-turn-helix domain-containing protein -
LJF36_RS22130 (4529652) 4529652..4529729 + 78 Protein_4303 porin family protein -
LJF36_RS22135 (4529829) 4529829..4530581 + 753 WP_000842433.1 non-specific acid phosphatase -
LJF36_RS22140 (4530829) 4530829..4531320 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
LJF36_RS22145 (4531317) 4531317..4531610 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LJF36_RS22150 (4531927) 4531927..4532148 + 222 WP_001576552.1 hypothetical protein -
LJF36_RS22155 (4532414) 4532414..4533289 + 876 WP_000921676.1 AraC family transcriptional regulator -
LJF36_RS22160 (4533286) 4533286..4533573 + 288 WP_001541332.1 transcriptional regulator RtsB -
LJF36_RS22165 (4533566) 4533566..4533874 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
LJF36_RS22170 (4533873) 4533873..4534121 + 249 Protein_4311 Ig-like domain-containing protein -
LJF36_RS22175 (4534233) 4534233..4534364 + 132 Protein_4312 hypothetical protein -
LJF36_RS22180 (4534658) 4534658..4535563 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T222106 WP_000626100.1 NZ_CP085824:c4531320-4530829 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T222106 NZ_CP117693:3382455-3382673 [Salmonella enterica subsp. enterica serovar London]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT222106 WP_001110452.1 NZ_CP085824:c4531610-4531317 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT222106 NZ_CP117693:3382053-3382427 [Salmonella enterica subsp. enterica serovar London]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References