Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4382808..4383358 Replicon chromosome
Accession NZ_CP085824
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Ivysaur

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag LJF36_RS21345 Protein ID WP_001199743.1
Coordinates 4382808..4383116 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag LJF36_RS21350 Protein ID WP_001118105.1
Coordinates 4383119..4383358 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF36_RS21325 (4379382) 4379382..4380122 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
LJF36_RS21330 (4380244) 4380244..4380774 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
LJF36_RS21335 (4381097) 4381097..4382230 + 1134 Protein_4151 IS3 family transposase -
LJF36_RS21340 (4382262) 4382262..4382402 - 141 Protein_4152 Arm DNA-binding domain-containing protein -
LJF36_RS21345 (4382808) 4382808..4383116 - 309 WP_001199743.1 CcdB family protein Toxin
LJF36_RS21350 (4383119) 4383119..4383358 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LJF36_RS21355 (4383467) 4383467..4383715 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
LJF36_RS21360 (4383792) 4383792..4384337 - 546 WP_223151225.1 helix-turn-helix domain-containing protein -
LJF36_RS21375 (4385094) 4385094..4386113 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
LJF36_RS21380 (4386141) 4386141..4386671 - 531 WP_000896758.1 gluconokinase -
LJF36_RS21385 (4386888) 4386888..4387919 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4381189..4384292 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T222104 WP_001199743.1 NZ_CP085824:c4383116-4382808 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T222104 NZ_CP117693:1955795-1955897 [Salmonella enterica subsp. enterica serovar London]
GCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT222104 WP_001118105.1 NZ_CP085824:c4383358-4383119 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT222104 NZ_CP117693:c1955899-1955756 [Salmonella enterica subsp. enterica serovar London]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References