Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4338547..4339123 Replicon chromosome
Accession NZ_CP085824
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Ivysaur

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag LJF36_RS21135 Protein ID WP_001131963.1
Coordinates 4338836..4339123 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag LJF36_RS21130 Protein ID WP_000063142.1
Coordinates 4338547..4338849 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF36_RS21115 (4335057) 4335057..4337207 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
LJF36_RS21120 (4337302) 4337302..4337505 + 204 WP_000460616.1 YbdD/YjiX family protein -
LJF36_RS21125 (4337516) 4337516..4338472 + 957 WP_000187843.1 GTPase -
LJF36_RS21130 (4338547) 4338547..4338849 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
LJF36_RS21135 (4338836) 4338836..4339123 - 288 WP_001131963.1 BrnT family toxin Toxin
LJF36_RS21140 (4339540) 4339540..4340796 + 1257 Protein_4112 NERD domain-containing protein/DEAD/DEAH box helicase -
LJF36_RS21145 (4340790) 4340790..4340969 + 180 Protein_4113 DNA methyltransferase -
LJF36_RS21150 (4340959) 4340959..4342263 + 1305 WP_000863534.1 type I restriction-modification protein specificity subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T222103 WP_001131963.1 NZ_CP085824:c4339123-4338836 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T222103 NZ_CP117693:853055-853453 [Salmonella enterica subsp. enterica serovar London]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT222103 WP_000063142.1 NZ_CP085824:c4338849-4338547 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT222103 NZ_CP117693:852828-853055 [Salmonella enterica subsp. enterica serovar London]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References