Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3763153..3763773 Replicon chromosome
Accession NZ_CP085824
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Ivysaur

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJF36_RS18485 Protein ID WP_001280991.1
Coordinates 3763555..3763773 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJF36_RS18480 Protein ID WP_000344807.1
Coordinates 3763153..3763527 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF36_RS18470 (3758292) 3758292..3759485 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LJF36_RS18475 (3759508) 3759508..3762657 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LJF36_RS18480 (3763153) 3763153..3763527 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJF36_RS18485 (3763555) 3763555..3763773 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LJF36_RS18490 (3763952) 3763952..3764503 + 552 WP_001278793.1 maltose O-acetyltransferase -
LJF36_RS18495 (3764621) 3764621..3765091 + 471 WP_000136183.1 YlaC family protein -
LJF36_RS18500 (3765147) 3765147..3765287 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJF36_RS18505 (3765293) 3765293..3765553 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJF36_RS18510 (3765778) 3765778..3767328 + 1551 WP_000213140.1 EAL domain-containing protein -
LJF36_RS18520 (3767559) 3767559..3767948 + 390 WP_000961287.1 MGMT family protein -
LJF36_RS18525 (3767981) 3767981..3768550 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T222099 WP_001280991.1 NZ_CP085824:3763555-3763773 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T222099 NZ_CP117692:848139-848429 [Ligilactobacillus ruminis]
ATGCGCTTGAAAAATAAGTACGATATTCAGTTCACCGGTCAGTTTAAGAGGGATTTCAAGCTTGCGAAAAAGCAGCATAG
GAATCTTGATAGATTGTTTAAAGTGATTGATGTTTTAGCGGCTGGCGGCACATTGGACGAAAAGTACAGAGATTATGCTC
TTACGGGTAATTACAAGGGCACACGCGAATGTCACGTTGAACCGGATTGCCTGCTCATCTATGAAATTCGCCAAGACGTG
CTGGTCTTGTTTCTTTACCCTAAAGGGGCGAGAATGCCCCCACTTCTCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT222099 WP_000344807.1 NZ_CP085824:3763153-3763527 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT222099 NZ_CP117692:847883-848155 [Ligilactobacillus ruminis]
ATGTCAACAACGAATTTAAACATCAGAACAGATAAGGATGTCAAAGAGAAAGCAGAGAAAATTTTCAATGAACTTGGATT
AAACATGACCAGTGCCGTAAATATTTTTCTGAGAACTGCTATTCGTGAACGCGGCATTCCGTTTGAATTGAAATTGGACG
TGCCGAACGAAACGACGATTGCAGCGATTGAAGAGGGGAGGAAAATGGCTTCCGATCCATCTTCACCAAGATATTCCAAC
ATTGATGAATTGAGGGATGCGCTTGAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References