Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 552199..552959 Replicon chromosome
Accession NZ_CP085824
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Ivysaur

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag LJF36_RS02610 Protein ID WP_000533912.1
Coordinates 552474..552959 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LJF36_RS02605 Protein ID WP_000965886.1
Coordinates 552199..552486 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF36_RS02585 (547604) 547604..548515 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
LJF36_RS02590 (548525) 548525..550594 + 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
LJF36_RS02595 (550984) 550984..551382 + 399 Protein_491 IS3 family transposase -
LJF36_RS02600 (551554) 551554..552021 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
LJF36_RS02605 (552199) 552199..552486 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LJF36_RS02610 (552474) 552474..552959 + 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
LJF36_RS02615 (553330) 553330..553869 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
LJF36_RS02620 (554043) 554043..554255 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJF36_RS02625 (554543) 554543..554833 - 291 WP_000455790.1 HTH-type transcriptional regulator -
LJF36_RS02630 (555272) 555272..555982 + 711 WP_000190524.1 DUF3053 domain-containing protein -
LJF36_RS02635 (556032) 556032..557006 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJF36_RS02640 (557225) 557225..557887 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T222083 WP_000533912.1 NZ_CP085824:552474-552959 [Salmonella enterica subsp. enterica serovar Enteritidis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T222083 NZ_CP117673:53850-53999 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT222083 WP_000965886.1 NZ_CP085824:552199-552486 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT222083 NZ_CP117673:c53806-53745 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References