Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4021733..4022353 Replicon chromosome
Accession NZ_CP085823
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Venusaur

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJF47_RS19500 Protein ID WP_001280991.1
Coordinates 4021733..4021951 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJF47_RS19505 Protein ID WP_000344807.1
Coordinates 4021979..4022353 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF47_RS19460 (4016956) 4016956..4017525 + 570 WP_000779802.1 YbaY family lipoprotein -
LJF47_RS19465 (4017558) 4017558..4017947 - 390 WP_000961287.1 MGMT family protein -
LJF47_RS19475 (4018178) 4018178..4019728 - 1551 WP_000213140.1 EAL domain-containing protein -
LJF47_RS19480 (4019953) 4019953..4020213 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJF47_RS19485 (4020219) 4020219..4020359 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJF47_RS19490 (4020415) 4020415..4020885 - 471 WP_000136183.1 YlaC family protein -
LJF47_RS19495 (4021003) 4021003..4021554 - 552 WP_001278793.1 maltose O-acetyltransferase -
LJF47_RS19500 (4021733) 4021733..4021951 - 219 WP_001280991.1 HHA domain-containing protein Toxin
LJF47_RS19505 (4021979) 4021979..4022353 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJF47_RS19510 (4022849) 4022849..4025998 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LJF47_RS19515 (4026021) 4026021..4027214 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T222080 WP_001280991.1 NZ_CP085823:c4021951-4021733 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T222080 NZ_CP085823:c4021951-4021733 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT222080 WP_000344807.1 NZ_CP085823:c4022353-4021979 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT222080 NZ_CP085823:c4022353-4021979 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References