Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3402013..3402563 Replicon chromosome
Accession NZ_CP085823
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Venusaur

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag LJF47_RS16640 Protein ID WP_001199743.1
Coordinates 3402255..3402563 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag LJF47_RS16635 Protein ID WP_001118105.1
Coordinates 3402013..3402252 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF47_RS16600 (3397452) 3397452..3398483 - 1032 WP_000453347.1 L-idonate 5-dehydrogenase -
LJF47_RS16605 (3398700) 3398700..3399230 + 531 WP_000896758.1 gluconokinase -
LJF47_RS16610 (3399258) 3399258..3400277 - 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
LJF47_RS16625 (3401034) 3401034..3401579 + 546 WP_223151225.1 helix-turn-helix domain-containing protein -
LJF47_RS16630 (3401656) 3401656..3401904 + 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
LJF47_RS16635 (3402013) 3402013..3402252 + 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LJF47_RS16640 (3402255) 3402255..3402563 + 309 WP_001199743.1 CcdB family protein Toxin
LJF47_RS16645 (3402969) 3402969..3403109 + 141 Protein_3237 Arm DNA-binding domain-containing protein -
LJF47_RS16650 (3403141) 3403141..3404274 - 1134 Protein_3238 IS3 family transposase -
LJF47_RS16655 (3404597) 3404597..3405127 + 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
LJF47_RS16660 (3405249) 3405249..3405989 + 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 3401079..3404182 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T222075 WP_001199743.1 NZ_CP085823:3402255-3402563 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T222075 NZ_CP117672:2661341-2661448 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT222075 WP_001118105.1 NZ_CP085823:3402013-3402252 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT222075 NZ_CP117672:c2661288-2661227 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References