Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1928389..1929049 Replicon chromosome
Accession NZ_CP085823
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Venusaur

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LJF47_RS09590 Protein ID WP_000244756.1
Coordinates 1928389..1928802 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LJF47_RS09595 Protein ID WP_000351186.1
Coordinates 1928783..1929049 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF47_RS09570 (1924330) 1924330..1926063 - 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -
LJF47_RS09575 (1926069) 1926069..1926782 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJF47_RS09580 (1926806) 1926806..1927702 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LJF47_RS09585 (1927815) 1927815..1928336 + 522 WP_001055885.1 flavodoxin FldB -
LJF47_RS09590 (1928389) 1928389..1928802 - 414 WP_000244756.1 protein YgfX Toxin
LJF47_RS09595 (1928783) 1928783..1929049 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LJF47_RS09600 (1929299) 1929299..1930279 + 981 WP_000874176.1 tRNA-modifying protein YgfZ -
LJF47_RS09605 (1930395) 1930395..1931054 - 660 WP_000250289.1 hemolysin III family protein -
LJF47_RS09610 (1931218) 1931218..1931529 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LJF47_RS09615 (1931687) 1931687..1933120 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T222067 WP_000244756.1 NZ_CP085823:c1928802-1928389 [Salmonella enterica subsp. enterica serovar Enteritidis]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T222067 NZ_CP117672:856387-856794 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT222067 WP_000351186.1 NZ_CP085823:c1929049-1928783 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT222067 NZ_CP117672:856140-856406 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References