Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4339338..4339998 Replicon chromosome
Accession NZ_CP085822
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Charmeleon

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LJF58_RS21145 Protein ID WP_000244756.1
Coordinates 4339585..4339998 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LJF58_RS21140 Protein ID WP_000351186.1
Coordinates 4339338..4339604 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF58_RS21120 (4335267) 4335267..4336700 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
LJF58_RS21125 (4336858) 4336858..4337169 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LJF58_RS21130 (4337333) 4337333..4337992 + 660 WP_000250289.1 hemolysin III family protein -
LJF58_RS21135 (4338108) 4338108..4339088 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
LJF58_RS21140 (4339338) 4339338..4339604 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LJF58_RS21145 (4339585) 4339585..4339998 + 414 WP_000244756.1 protein YgfX Toxin
LJF58_RS21150 (4340051) 4340051..4340572 - 522 WP_001055885.1 flavodoxin FldB -
LJF58_RS21155 (4340685) 4340685..4341581 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LJF58_RS21160 (4341605) 4341605..4342318 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJF58_RS21165 (4342324) 4342324..4344057 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T222052 WP_000244756.1 NZ_CP085822:4339585-4339998 [Salmonella enterica subsp. enterica serovar Enteritidis]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T222052 NZ_CP117668:c2750739-2750212 [Escherichia albertii]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTTTGCGAGCGTGTATCCTTTGTAGCAACACTC
CAGAACGTCAGGTCCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGCTCAGCCTCATTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCTCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCGTTGGTTGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT222052 WP_000351186.1 NZ_CP085822:4339338-4339604 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT222052 NZ_CP117668:c2751012-2750746 [Escherichia albertii]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAATCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGTTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References