Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3824621..3825207 Replicon chromosome
Accession NZ_CP085822
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Charmeleon

Toxin (Protein)


Gene name doc Uniprot ID A0A3V9X0E4
Locus tag LJF58_RS18585 Protein ID WP_000174964.1
Coordinates 3824839..3825207 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID V7IU48
Locus tag LJF58_RS18580 Protein ID WP_001522145.1
Coordinates 3824621..3824842 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF58_RS18555 (3819642) 3819642..3820751 + 1110 WP_000822978.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
LJF58_RS18560 (3820811) 3820811..3821737 + 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LJF58_RS18565 (3821734) 3821734..3823011 + 1278 WP_000803764.1 branched chain amino acid ABC transporter permease LivM -
LJF58_RS18570 (3823008) 3823008..3823775 + 768 WP_000082080.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
LJF58_RS18575 (3823777) 3823777..3824490 + 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
LJF58_RS18580 (3824621) 3824621..3824842 + 222 WP_001522145.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LJF58_RS18585 (3824839) 3824839..3825207 + 369 WP_000174964.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LJF58_RS18590 (3825466) 3825466..3826782 + 1317 WP_000624755.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
LJF58_RS18595 (3826887) 3826887..3827774 + 888 WP_000099303.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
LJF58_RS18600 (3827771) 3827771..3828616 + 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
LJF58_RS18605 (3828618) 3828618..3829688 + 1071 WP_000907840.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3819642..3830425 10783


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(6-114)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13601.91 Da        Isoelectric Point: 6.7252

>T222050 WP_000174964.1 NZ_CP085822:3824839-3825207 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIVVRLRA

Download         Length: 369 bp

>T222050 NZ_CP117668:c2000342-2000190 [Escherichia albertii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GCTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8166.17 Da        Isoelectric Point: 5.0775

>AT222050 WP_001522145.1 NZ_CP085822:3824621-3824842 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp

>AT222050 NZ_CP117668:2000387-2000434 [Escherichia albertii]
GTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9X0E4

Antitoxin

Source ID Structure

References