Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 3714492..3715252 | Replicon | chromosome |
| Accession | NZ_CP085822 | ||
| Organism | Salmonella enterica subsp. enterica serovar Enteritidis strain Charmeleon | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A1R2W0C7 |
| Locus tag | LJF58_RS18100 | Protein ID | WP_000533912.1 |
| Coordinates | 3714767..3715252 (+) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | M7RHS4 |
| Locus tag | LJF58_RS18095 | Protein ID | WP_000965886.1 |
| Coordinates | 3714492..3714779 (+) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF58_RS18075 (3709897) | 3709897..3710808 | + | 912 | WP_001168551.1 | glycine--tRNA ligase subunit alpha | - |
| LJF58_RS18080 (3710818) | 3710818..3712887 | + | 2070 | WP_001291741.1 | glycine--tRNA ligase subunit beta | - |
| LJF58_RS18085 (3713277) | 3713277..3713675 | + | 399 | Protein_3519 | IS3 family transposase | - |
| LJF58_RS18090 (3713847) | 3713847..3714314 | + | 468 | WP_000702452.1 | GNAT family N-acetyltransferase | - |
| LJF58_RS18095 (3714492) | 3714492..3714779 | + | 288 | WP_000965886.1 | DUF1778 domain-containing protein | Antitoxin |
| LJF58_RS18100 (3714767) | 3714767..3715252 | + | 486 | WP_000533912.1 | GNAT family N-acetyltransferase | Toxin |
| LJF58_RS18105 (3715623) | 3715623..3716162 | - | 540 | WP_000047147.1 | copper-binding periplasmic metallochaperone CueP | - |
| LJF58_RS18110 (3716336) | 3716336..3716548 | - | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
| LJF58_RS18115 (3716836) | 3716836..3717126 | - | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
| LJF58_RS18120 (3717565) | 3717565..3718275 | + | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
| LJF58_RS18125 (3718325) | 3718325..3719299 | - | 975 | WP_000804678.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
| LJF58_RS18130 (3719518) | 3719518..3720180 | - | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17731.46 Da Isoelectric Point: 9.8719
>T222049 WP_000533912.1 NZ_CP085822:3714767-3715252 [Salmonella enterica subsp. enterica serovar Enteritidis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
>T222049 NZ_CP117668:1897175-1897555 [Escherichia albertii]
ATGCAAACTTTACCTTTACCCGAGCCTCGGGCGGCTCGACCATGCCCATCGCCCGTGCAGGTCTGGCAGCTGCTACTCAC
TCATCTGCTGAATAAACACTACGGCCTCACACTGAACGACACGCCGTTTGGCGACGACAGAGTGATTCAGGCGCACATCA
ACGCTGGCATTTCTCTGTGCGACGCCGTCAACTTCATTGTGGAACGGTATGAACTGGTGCGCATCGACCACAGCCGTTTC
GGCCTCACCGAGCGCTCATCGCTGATTGGTGCCATCGACATCCTGCGAGCCCGCCGTGCAACCGGGCTGATAGTAAGTAG
TGGCTACAGCACCATCACCCGCATCACAACGGGCCGGTATTGGGAGGATACAGCACAGTGA
ATGCAAACTTTACCTTTACCCGAGCCTCGGGCGGCTCGACCATGCCCATCGCCCGTGCAGGTCTGGCAGCTGCTACTCAC
TCATCTGCTGAATAAACACTACGGCCTCACACTGAACGACACGCCGTTTGGCGACGACAGAGTGATTCAGGCGCACATCA
ACGCTGGCATTTCTCTGTGCGACGCCGTCAACTTCATTGTGGAACGGTATGAACTGGTGCGCATCGACCACAGCCGTTTC
GGCCTCACCGAGCGCTCATCGCTGATTGGTGCCATCGACATCCTGCGAGCCCGCCGTGCAACCGGGCTGATAGTAAGTAG
TGGCTACAGCACCATCACCCGCATCACAACGGGCCGGTATTGGGAGGATACAGCACAGTGA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10950.60 Da Isoelectric Point: 4.6811
>AT222049 WP_000965886.1 NZ_CP085822:3714492-3714779 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
Download Length: 288 bp
>AT222049 NZ_CP117668:1896818-1897144 [Escherichia albertii]
ATGCATTCTGAACAATGGGGACTGACGTGCGGTAAAAAGCCGTGCTTCAGTGCCAGGCTGGTACAGGAAGGCAACCGGCT
GCACTTCCTGGCCGACTGGGCAGGGTTTACCGGAAAATTCAGCAACGATGAGGCATTGCGCCTTGACCAAGCGTTTCCGC
TGATAATGAAGCAGCTGGAACAAAAGCTTTCAGCCGGTGAGCTGAATTCCCGCCGTCAGCAGTGCGTCACTCTGCATCAC
ATCGGGCTGACCTGCAAAGCCGACACGCTCGGTTCACACGGCTACCTTTACATCGCGATTTACCCTTCAGCGACAGCAAC
CGGATGA
ATGCATTCTGAACAATGGGGACTGACGTGCGGTAAAAAGCCGTGCTTCAGTGCCAGGCTGGTACAGGAAGGCAACCGGCT
GCACTTCCTGGCCGACTGGGCAGGGTTTACCGGAAAATTCAGCAACGATGAGGCATTGCGCCTTGACCAAGCGTTTCCGC
TGATAATGAAGCAGCTGGAACAAAAGCTTTCAGCCGGTGAGCTGAATTCCCGCCGTCAGCAGTGCGTCACTCTGCATCAC
ATCGGGCTGACCTGCAAAGCCGACACGCTCGGTTCACACGGCTACCTTTACATCGCGATTTACCCTTCAGCGACAGCAAC
CGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1R2W0C7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK8 | |
| AlphaFold DB | A0A3V2JDX2 |