Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3013834..3014615 Replicon chromosome
Accession NZ_CP085822
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Charmeleon

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag LJF58_RS14890 Protein ID WP_000626100.1
Coordinates 3013834..3014325 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LJF58_RS14895 Protein ID WP_001110452.1
Coordinates 3014322..3014615 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF58_RS14855 (3009294) 3009294..3009641 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
LJF58_RS14860 (3009617) 3009617..3011320 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
LJF58_RS14865 (3011357) 3011357..3011932 + 576 WP_001188509.1 transcriptional regulator -
LJF58_RS14875 (3012203) 3012203..3012277 - 75 Protein_2905 helix-turn-helix domain-containing protein -
LJF58_RS14880 (3012657) 3012657..3012734 + 78 Protein_2906 porin family protein -
LJF58_RS14885 (3012834) 3012834..3013586 + 753 WP_000842433.1 non-specific acid phosphatase -
LJF58_RS14890 (3013834) 3013834..3014325 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
LJF58_RS14895 (3014322) 3014322..3014615 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LJF58_RS14900 (3014932) 3014932..3015153 + 222 WP_001576552.1 hypothetical protein -
LJF58_RS14905 (3015419) 3015419..3016294 + 876 WP_000921676.1 AraC family transcriptional regulator -
LJF58_RS14910 (3016291) 3016291..3016578 + 288 WP_001541332.1 transcriptional regulator RtsB -
LJF58_RS14915 (3016571) 3016571..3016879 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
LJF58_RS14920 (3016878) 3016878..3017126 + 249 Protein_2914 Ig-like domain-containing protein -
LJF58_RS14925 (3017238) 3017238..3017369 + 132 Protein_2915 hypothetical protein -
LJF58_RS14930 (3017663) 3017663..3018568 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T222046 WP_000626100.1 NZ_CP085822:c3014325-3013834 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T222046 NZ_CP117668:c727480-727094 [Escherichia albertii]
ATGATTTGGGTCAGTGCACAGGAGGTCATTGCCTTCCACGATCGAATTTTGCAACGTTTTCCCGGTGTGGCGGGCCTGGC
CGACCCCGGCAGAGCACAGGCGCTGATTTATCGCGTGCAGAACCGTGTTCACTACGAGGGCGTTACTGACCTGTTTGAAC
TGGCAGCAACCTACTGGGTTGCCATCGCTCGCGGTCACATCTTTCATGATGGTAATAAACGTACCGCATTTTTCGTTACT
ATGACCTTTCTTTGGCGCAATGGCATCCGTATCCGTGACGTTGATAACTCGCTGGAGAACCTGACTGTCGAAGCGGCTAC
CGGAGAAAAAACGGTCGGTCAATTAGCGCGATGTTTACGTGAACGAGTGGATAGTTCCGGGAATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT222046 WP_001110452.1 NZ_CP085822:c3014615-3014322 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT222046 NZ_CP117668:c727698-727477 [Escherichia albertii]
ATGCAAACTTACACTTCCACACAAGCCAGAGCCAATATTGCCACTGTACTGGATACCGCGTTGAATGGTGAGCCAGTTGA
AATCACCCGTCGCGACGGCAGCTCTGCCGTGCTCATTAGTAAAGCCGCATTCGAGGCGTATCAAAATGCGAAACTGGACG
CGGAATTTGATGCCATCATGCAACGTCATGAACACACAATTGAAGCGTTAACTGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References