Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2865813..2866363 Replicon chromosome
Accession NZ_CP085822
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Charmeleon

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag LJF58_RS14095 Protein ID WP_001199743.1
Coordinates 2865813..2866121 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag LJF58_RS14100 Protein ID WP_001118105.1
Coordinates 2866124..2866363 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF58_RS14075 (2862387) 2862387..2863127 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
LJF58_RS14080 (2863249) 2863249..2863779 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
LJF58_RS14085 (2864102) 2864102..2865235 + 1134 Protein_2754 IS3 family transposase -
LJF58_RS14090 (2865267) 2865267..2865407 - 141 Protein_2755 Arm DNA-binding domain-containing protein -
LJF58_RS14095 (2865813) 2865813..2866121 - 309 WP_001199743.1 CcdB family protein Toxin
LJF58_RS14100 (2866124) 2866124..2866363 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LJF58_RS14105 (2866472) 2866472..2866720 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
LJF58_RS14110 (2866797) 2866797..2867342 - 546 WP_223151225.1 helix-turn-helix domain-containing protein -
LJF58_RS14125 (2868099) 2868099..2869118 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
LJF58_RS14130 (2869146) 2869146..2869676 - 531 WP_000896758.1 gluconokinase -
LJF58_RS14135 (2869893) 2869893..2870924 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 2864194..2867297 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T222044 WP_001199743.1 NZ_CP085822:c2866121-2865813 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T222044 NZ_CP117668:580602-580757 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT222044 WP_001118105.1 NZ_CP085822:c2866363-2866124 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT222044 NZ_CP117668:c580590-580532 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References