Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 2821552..2822128 Replicon chromosome
Accession NZ_CP085822
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Charmeleon

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag LJF58_RS13885 Protein ID WP_001131963.1
Coordinates 2821841..2822128 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag LJF58_RS13880 Protein ID WP_000063142.1
Coordinates 2821552..2821854 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF58_RS13865 (2818062) 2818062..2820212 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
LJF58_RS13870 (2820307) 2820307..2820510 + 204 WP_000460616.1 YbdD/YjiX family protein -
LJF58_RS13875 (2820521) 2820521..2821477 + 957 WP_000187843.1 GTPase -
LJF58_RS13880 (2821552) 2821552..2821854 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
LJF58_RS13885 (2821841) 2821841..2822128 - 288 WP_001131963.1 BrnT family toxin Toxin
LJF58_RS13890 (2822545) 2822545..2823801 + 1257 Protein_2715 NERD domain-containing protein/DEAD/DEAH box helicase -
LJF58_RS13895 (2823795) 2823795..2823974 + 180 Protein_2716 DNA methyltransferase -
LJF58_RS13900 (2823964) 2823964..2825268 + 1305 WP_000863534.1 type I restriction-modification protein specificity subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T222043 WP_001131963.1 NZ_CP085822:c2822128-2821841 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T222043 NZ_CP117668:c567322-567128 [Escherichia albertii]
ATGCGATATGAAAAAGTTAAGCCATGTCCGTTTTGTGGTTGTCCATCTGTAACAGTGAAAGCCATTTCAGGGTATTACCG
GGCAAAATGCAACGGCTGCGAATCCCGAACTGGCTATGGTGGAAGTGATAAAGAAGCCCTCGAAAGATGGAATAAACGAA
CCGCTGAAAATATTAATGGAGGCATCTATGTATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT222043 WP_000063142.1 NZ_CP085822:c2821854-2821552 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT222043 NZ_CP117668:566952-567129 [Escherichia albertii]
AGGAATGAAGTTTCTCGCAATTAAAATTCATCAGTTTTACTTTTTGCTCTCTGGAAACGCCTGCTTCTTTTTTCCCTGAG
AGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTACCACCTTCCTTTTC
AATTGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References