Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2246022..2246642 Replicon chromosome
Accession NZ_CP085822
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Charmeleon

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJF58_RS11235 Protein ID WP_001280991.1
Coordinates 2246424..2246642 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJF58_RS11230 Protein ID WP_000344807.1
Coordinates 2246022..2246396 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF58_RS11220 (2241161) 2241161..2242354 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LJF58_RS11225 (2242377) 2242377..2245526 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LJF58_RS11230 (2246022) 2246022..2246396 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJF58_RS11235 (2246424) 2246424..2246642 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LJF58_RS11240 (2246821) 2246821..2247372 + 552 WP_001278793.1 maltose O-acetyltransferase -
LJF58_RS11245 (2247490) 2247490..2247960 + 471 WP_000136183.1 YlaC family protein -
LJF58_RS11250 (2248016) 2248016..2248156 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJF58_RS11255 (2248162) 2248162..2248422 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJF58_RS11260 (2248647) 2248647..2250197 + 1551 WP_000213140.1 EAL domain-containing protein -
LJF58_RS11270 (2250428) 2250428..2250817 + 390 WP_000961287.1 MGMT family protein -
LJF58_RS11275 (2250850) 2250850..2251419 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T222039 WP_001280991.1 NZ_CP085822:2246424-2246642 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T222039 NZ_CP117662:c9620-9315 [Escherichia albertii]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGTATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGGGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT222039 WP_000344807.1 NZ_CP085822:2246022-2246396 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT222039 NZ_CP117662:c9840-9622 [Escherichia albertii]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGCTGCTCAAGGCGTATGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGGCGACTGCGCGCTGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCAG
AGGTCGCTAGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References