Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 714010..714635 Replicon chromosome
Accession NC_009565
Organism Mycobacterium tuberculosis F11

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag TBFG_RS03235 Protein ID WP_003403218.1
Coordinates 714234..714635 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag TBFG_RS03230 Protein ID WP_003403213.1
Coordinates 714010..714237 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBFG_RS03200 709189..709410 - 222 WP_003898525.1 DUF4926 domain-containing protein -
TBFG_RS03205 709552..710157 + 606 WP_003898526.1 hypothetical protein -
TBFG_RS03210 710176..712743 - 2568 WP_009937370.1 SEC-C domain-containing protein -
TBFG_RS03215 712827..713576 + 750 WP_003898528.1 hypothetical protein -
TBFG_RS03220 713573..713815 + 243 WP_003403210.1 hypothetical protein -
TBFG_RS03230 714010..714237 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
TBFG_RS03235 714234..714635 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
TBFG_RS22320 714764..715459 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
TBFG_RS22325 715456..715947 + 492 WP_012054156.1 galactose-1-phosphate uridylyltransferase -
TBFG_RS03245 715944..717035 + 1092 WP_012054241.1 galactokinase -
TBFG_RS03255 717430..718494 + 1065 WP_003898532.1 hypothetical protein -
TBFG_RS03260 718598..719545 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T22203 WP_003403218.1 NC_009565:714234-714635 [Mycobacterium tuberculosis F11]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T22203 NC_009565:714234-714635 [Mycobacterium tuberculosis F11]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT22203 WP_003403213.1 NC_009565:714010-714237 [Mycobacterium tuberculosis F11]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT22203 NC_009565:714010-714237 [Mycobacterium tuberculosis F11]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References