Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4165882..4166642 Replicon chromosome
Accession NZ_CP085821
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Charizard

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag LJF63_RS20395 Protein ID WP_000533912.1
Coordinates 4165882..4166367 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LJF63_RS20400 Protein ID WP_000965886.1
Coordinates 4166355..4166642 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF63_RS20365 (4160954) 4160954..4161616 + 663 WP_000747548.1 OmpA family lipoprotein -
LJF63_RS20370 (4161835) 4161835..4162809 + 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJF63_RS20375 (4162859) 4162859..4163569 - 711 WP_000190524.1 DUF3053 domain-containing protein -
LJF63_RS20380 (4164008) 4164008..4164298 + 291 WP_000455790.1 HTH-type transcriptional regulator -
LJF63_RS20385 (4164586) 4164586..4164798 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJF63_RS20390 (4164972) 4164972..4165511 + 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
LJF63_RS20395 (4165882) 4165882..4166367 - 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
LJF63_RS20400 (4166355) 4166355..4166642 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LJF63_RS20405 (4166820) 4166820..4167287 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
LJF63_RS20410 (4167459) 4167459..4167857 - 399 Protein_3987 IS3 family transposase -
LJF63_RS20415 (4168247) 4168247..4170316 - 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
LJF63_RS20420 (4170326) 4170326..4171237 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T222026 WP_000533912.1 NZ_CP085821:c4166367-4165882 [Salmonella enterica subsp. enterica serovar Enteritidis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T222026 NZ_CP117659:1054261-1054413 [Escherichia albertii]
ATGCTAACAAAATATGCCCTTGTGGCAATCATAGTGCTGTGTTGTACAGTGCTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT222026 WP_000965886.1 NZ_CP085821:c4166642-4166355 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT222026 NZ_CP117659:c1054219-1054167 [Escherichia albertii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References